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  Age-related structural abnormalities in the human retina-choroid complex revealed by two-photon excited autofluorescence imaging

Han, M., Giese, G., Schmitz-Valckenberg, S., Bindewald-Wittich, A., Holz, F. G., Yu, J., et al. (2007). Age-related structural abnormalities in the human retina-choroid complex revealed by two-photon excited autofluorescence imaging. Journal of Biomedical Optics, 12(2): 024012, pp. 24012-24018. doi:10.1117/1.2717522.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-692A-A Version Permalink: http://hdl.handle.net/21.11116/0000-0002-692B-9
Genre: Journal Article

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JBiomedicalOpt_12_2007_024012.pdf (Any fulltext), 471KB
 
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 Creators:
Han, Meng, Author
Giese, Günter1, Author              
Schmitz-Valckenberg, Steffen, Author
Bindewald-Wittich, Almut, Author
Holz, Frank G., Author
Yu, Jiayi, Author
Bille, Josef F., Author
Niemz, Markolf H., Author
Affiliations:
1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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Free keywords: two-photon imaging; autofluorescence; retina; choroid
 Abstract: The intensive metabolism of photoreceptors is delicately maintained by the retinal pigment epithelium (RPE) and the choroid. Dysfunction of either the RPE or choroid may lead to severe damage to the retina. Two-photon excited autofluorescence (TPEF) from endogenous fluorophores in the human retina provides a novel opportunity to reveal age-related structural abnormalities in the retina-choroid complex prior to apparent pathological manifestations of age-related retinal diseases. In the photoreceptor layer, the regularity of the macular photoreceptor mosaic is preserved during aging. In the RPE, enlarged lipofuscin granules demonstrate significantly blue-shifted autofluorescence, which coincides with the depletion of melanin pigments. Prominent fibrillar structures in elderly Bruch's membrane and choriocapillaries represent choroidal structure and permeability alterations. Requiring neither slicing nor labeling, TPEF imaging is an elegant and highly efficient tool to delineate the thick, fragile, and opaque retina-choroid complex, and may provide clues to the trigger events of age-related macular degeneration.

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Language(s): eng - English
 Dates: 2006-12-292006-08-112007-01-022007-04-182007-04-18
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Journal of Biomedical Optics
Source Genre: Journal
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Publ. Info: Bellingham, WA : Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society
Pages: - Volume / Issue: 12 (2) Sequence Number: 024012 Start / End Page: 24012 - 24018 Identifier: ISSN: 1083-3668
CoNE: https://pure.mpg.de/cone/journals/resource/954925607859