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  Hexadirectional modulation of high-frequency electrophysiological activity in the human anterior medial temporal lobe maps visual space

Staudigl, T., Leszczynski, M., Jacobs, J., Sheth, S. A., Schroeder, C. E., Jensen, O., et al. (2018). Hexadirectional modulation of high-frequency electrophysiological activity in the human anterior medial temporal lobe maps visual space. Current Biology, 28(20), 3325-3329.e1–e4. doi:10.1016/j.cub.2018.09.035.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-6B21-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-995A-C
Genre: Journal Article

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 Creators:
Staudigl, Tobias1, 2, Author
Leszczynski, Marcin3, 4, Author
Jacobs, Joshua5, Author
Sheth, Sameer A.3, Author
Schroeder, Charles E.3, 4, Author
Jensen, Ole6, Author
Doeller, Christian F.7, 8, Author              
Affiliations:
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
2Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA, ou_persistent22              
3Department of Neurological Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA, ou_persistent22              
4Translational Neuroscience Laboratories, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA, ou_persistent22              
5Department of Biomedical Engineering, Columbia University in the City of New York, NY, USA, ou_persistent22              
6Centre for Human Brain Health (CHBH), School of Psychology, University of Birmingham, United Kingdom, ou_persistent22              
7Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Kavli Institute, Norwegian University of Science and Technology, Trondheim, Norway, ou_persistent22              
8Department Psychology (Doeller), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2591710              

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Free keywords: Grid coding; Visual space; Magnetoencephalography; Intracranial electroencephalography; Navigation; Entorhinal cortex; Eye movements
 Abstract: Grid cells are one of the core building blocks of spatial navigation [1]. Single-cell recordings of grid cells in the rodent entorhinal cortex revealed hexagonal coding of the local environment during spatial navigation [1]. Grid-like activity has also been identified in human single-cell recordings during virtual navigation [2]. Human fMRI studies further provide evidence that grid-like signals are also accessible on a macroscopic level [3, 4, 5, 6, 7]. Studies in both non-human primates [8] and humans [9, 10] suggest that grid-like coding in the entorhinal cortex generalizes beyond spatial navigation during locomotion, providing evidence for grid-like mapping of visual space during visual exploration—akin to the grid cell positional code in rodents during spatial navigation. However, electrophysiological correlates of the grid code in humans remain unknown. Here, we provide evidence for grid-like, hexadirectional coding of visual space by human high-frequency activity, based on two independent datasets: non-invasive magnetoencephalography (MEG) in healthy subjects and entorhinal intracranial electroencephalography (EEG) recordings in an epileptic patient. Both datasets consistently show a hexadirectional modulation of broadband high-frequency activity (60–120 Hz). Our findings provide first evidence for a grid-like MEG signal, indicating that the human entorhinal cortex codes visual space in a grid-like manner [8, 9, 10], and support the view that grid coding generalizes beyond environmental mapping during locomotion [4, 5, 6, 11]. Due to their millisecond accuracy, MEG recordings allow linking of grid-like activity to epochs during relevant behavior, thereby opening up the possibility for new MEG-based investigations of grid coding at high temporal resolution.

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Language(s): eng - English
 Dates: 2018-07-022018-04-192018-09-152018-10-112018-10-22
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.cub.2018.09.035
PMID: 30318353
Other: Epub 2018
 Degree: -

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Project name : At first glance: How saccades drive communication between the visual system and the hippocampus during memory formation / VisHipMem
Grant ID : 661373
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society
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Grant ID : -
Funding program : -
Funding organization : Kavli Foundation
Project name : Cognitive Geometry: Deciphering neural concept spaces and engineering knowledge to empower smart brains in a smart society / GEOCOG
Grant ID : 724836
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : 223262/F50
Funding program : -
Funding organization : Centre of Excellence scheme of the Research Council of Norway—Centre for Neural Computation
Project name : -
Grant ID : -
Funding program : -
Funding organization : Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits
Project name : NORBRAIN
Grant ID : 197467/F50
Funding program : National Infrastructure scheme of the Research Council of Norway
Funding organization : Research Council of Norway
Project name : -
Grant ID : 452-12-009
Funding program : Vidi Grant
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : 024-001-006
Funding program : NWO-Gravitation
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : 406-14-114 ; 406-15-291
Funding program : NWO-MaGW
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : R01-MH104606 ; S10 OD018211 ; P50-MH109429 ; EY024776 ; U01-NS098976 ; MH 106700
Funding program : -
Funding organization : National Institutes of Health (NIH)
Project name : -
Grant ID : BCS-1724243
Funding program : -
Funding organization : National Science Foundation (NSF)
Project name : -
Grant ID : -
Funding program : -
Funding organization : McDonnell Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : Dana Foundation
Project name : -
Grant ID : 220020448
Funding program : -
Funding organization : Wellcome Trust
Project name : -
Grant ID : -
Funding program : Royal Society Wolfson Research Merit Award
Funding organization : The Royal Society

Source 1

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Title: Current Biology
  Other : Curr. Biol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London, UK : Cell Press
Pages: - Volume / Issue: 28 (20) Sequence Number: - Start / End Page: 3325 - 3329.e1–e4 Identifier: ISSN: 0960-9822
CoNE: https://pure.mpg.de/cone/journals/resource/954925579107