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  Hexadirectional modulation of high-frequency electrophysiological activity in the human anterior medial temporal lobe maps visual space

Staudigl, T., Leszczynski, M., Jacobs, J., Sheth, S. A., Schroeder, C. E., Jensen, O., et al. (2018). Hexadirectional modulation of high-frequency electrophysiological activity in the human anterior medial temporal lobe maps visual space. Current Biology, 28(20), 3325-3329.e1–e4. doi:10.1016/j.cub.2018.09.035.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0002-6B21-1 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000A-5F21-7
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 Urheber:
Staudigl, Tobias1, 2, Autor
Leszczynski, Marcin3, 4, Autor
Jacobs, Joshua5, Autor
Sheth, Sameer A.3, Autor
Schroeder, Charles E.3, 4, Autor
Jensen, Ole6, Autor
Doeller, Christian F.7, 8, Autor           
Affiliations:
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
2Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA, ou_persistent22              
3Department of Neurological Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA, ou_persistent22              
4Translational Neuroscience Laboratories, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA, ou_persistent22              
5Department of Biomedical Engineering, Columbia University in the City of New York, NY, USA, ou_persistent22              
6Centre for Human Brain Health (CHBH), School of Psychology, University of Birmingham, United Kingdom, ou_persistent22              
7Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Kavli Institute, Norwegian University of Science and Technology, Trondheim, Norway, ou_persistent22              
8Department Psychology (Doeller), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2591710              

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Schlagwörter: Grid coding; Visual space; Magnetoencephalography; Intracranial electroencephalography; Navigation; Entorhinal cortex; Eye movements
 Zusammenfassung: Grid cells are one of the core building blocks of spatial navigation [1]. Single-cell recordings of grid cells in the rodent entorhinal cortex revealed hexagonal coding of the local environment during spatial navigation [1]. Grid-like activity has also been identified in human single-cell recordings during virtual navigation [2]. Human fMRI studies further provide evidence that grid-like signals are also accessible on a macroscopic level [3, 4, 5, 6, 7]. Studies in both non-human primates [8] and humans [9, 10] suggest that grid-like coding in the entorhinal cortex generalizes beyond spatial navigation during locomotion, providing evidence for grid-like mapping of visual space during visual exploration—akin to the grid cell positional code in rodents during spatial navigation. However, electrophysiological correlates of the grid code in humans remain unknown. Here, we provide evidence for grid-like, hexadirectional coding of visual space by human high-frequency activity, based on two independent datasets: non-invasive magnetoencephalography (MEG) in healthy subjects and entorhinal intracranial electroencephalography (EEG) recordings in an epileptic patient. Both datasets consistently show a hexadirectional modulation of broadband high-frequency activity (60–120 Hz). Our findings provide first evidence for a grid-like MEG signal, indicating that the human entorhinal cortex codes visual space in a grid-like manner [8, 9, 10], and support the view that grid coding generalizes beyond environmental mapping during locomotion [4, 5, 6, 11]. Due to their millisecond accuracy, MEG recordings allow linking of grid-like activity to epochs during relevant behavior, thereby opening up the possibility for new MEG-based investigations of grid coding at high temporal resolution.

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Sprache(n): eng - English
 Datum: 2018-07-022018-04-192018-09-152018-10-112018-10-22
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.cub.2018.09.035
PMID: 30318353
Anderer: Epub 2018
 Art des Abschluß: -

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Projektinformation

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Projektname : At first glance: How saccades drive communication between the visual system and the hippocampus during memory formation / VisHipMem
Grant ID : 661373
Förderprogramm : Horizon 2020
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Max Planck Society
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Kavli Foundation
Projektname : Cognitive Geometry: Deciphering neural concept spaces and engineering knowledge to empower smart brains in a smart society / GEOCOG
Grant ID : 724836
Förderprogramm : Horizon 2020
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : 223262/F50
Förderprogramm : -
Förderorganisation : Centre of Excellence scheme of the Research Council of Norway—Centre for Neural Computation
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits
Projektname : NORBRAIN
Grant ID : 197467/F50
Förderprogramm : National Infrastructure scheme of the Research Council of Norway
Förderorganisation : Research Council of Norway
Projektname : -
Grant ID : 452-12-009
Förderprogramm : Vidi Grant
Förderorganisation : Netherlands Organisation for Scientific Research (NWO)
Projektname : -
Grant ID : 024-001-006
Förderprogramm : NWO-Gravitation
Förderorganisation : Netherlands Organisation for Scientific Research (NWO)
Projektname : -
Grant ID : 406-14-114 ; 406-15-291
Förderprogramm : NWO-MaGW
Förderorganisation : Netherlands Organisation for Scientific Research (NWO)
Projektname : -
Grant ID : R01-MH104606 ; S10 OD018211 ; P50-MH109429 ; EY024776 ; U01-NS098976 ; MH 106700
Förderprogramm : -
Förderorganisation : National Institutes of Health (NIH)
Projektname : -
Grant ID : BCS-1724243
Förderprogramm : -
Förderorganisation : National Science Foundation (NSF)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : McDonnell Foundation
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Dana Foundation
Projektname : -
Grant ID : 220020448
Förderprogramm : -
Förderorganisation : Wellcome Trust
Projektname : -
Grant ID : -
Förderprogramm : Royal Society Wolfson Research Merit Award
Förderorganisation : The Royal Society

Quelle 1

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Titel: Current Biology
  Andere : Curr. Biol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: London, UK : Cell Press
Seiten: - Band / Heft: 28 (20) Artikelnummer: - Start- / Endseite: 3325 - 3329.e1–e4 Identifikator: ISSN: 0960-9822
CoNE: https://pure.mpg.de/cone/journals/resource/954925579107