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  Beneficial effects of leptin substitution on impaired eating behavior in lipodystrophy are sustained beyond 150 weeks of treatment

Püschel, J., Miehle, K., Mueller, K., Villringer, A., Stumvoll, M., Fasshauer, M., et al. (2019). Beneficial effects of leptin substitution on impaired eating behavior in lipodystrophy are sustained beyond 150 weeks of treatment. Cytokine, 113, 400-404. doi:10.1016/j.cyto.2018.10.012.

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Genre: Journal Article


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Püschel, Janett1, 2, Author
Miehle, Konstanze1, Author
Mueller, Karsten3, Author              
Villringer, Arno4, 5, Author              
Stumvoll, Michael1, Author
Fasshauer, Mathias1, 2, 6, Author
Schlögl, Haiko1, Author
1Department of Medicine, University Hospital Leipzig, Germany, ou_persistent22              
2Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
3Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
6Institute of Nutritional Science, Justus Liebig University, Gießen, Germany, ou_persistent22              


Free keywords: Leptin; Metreleptin; Lipodystrophy; Eating behavior; Hunger regulation
 Abstract: Aim Metreleptin treatment in lipodystrophy patients improves eating behavior with increased satiety and reduced hunger. However, no data are available whether effects are maintained beyond 52 weeks of treatment. Methods A prospective study with measurements at baseline and at >150 weeks of metreleptin treatment was performed. Five female lipodystrophy patients with indication for metreleptin were included. Behavioral aspects of hunger- and satiety regulation were assessed by validated eating behavior questionnaires and visual analog scales assessing hunger and satiety feelings before and after a standardized meal. Results Hunger rated on visual analog scales at 120 min after the meal significantly decreased from 46 ± 10 mm at baseline to 17 ± 6 mm at long-term assessment. Furthermore, satiety at 5 and 120 min after the meal significantly increased from baseline to long-term assessment (5 min: 70 ± 7 mm to 87 ± 3 mm; 120 min: 43 ± 10 mm to 79 ± 8 mm). On the Three Factor Eating Questionnaire, the mean value of factor 3 (hunger) significantly decreased from 9.2 ± 0.2 at baseline to 2.6 ± 1.5 at long-term assessment. In the Inventory of Eating Behavior and Weight Problems Questionnaire, mean values for scale 2 (strength and triggering of desire to eat) and scale 7 (cognitive restraint of eating) significantly decreased from baseline (31.6 ± 4.8 and 11.4 ± 2.2, respectively) to long-term assessment (14.0 ± 2.1 and 10.0 ± 1.9). Conclusion First evidence is presented that long-term metreleptin treatment of >150 weeks has sustained effects on eating behavior with increased satiety, as well as reduced hunger and hunger-related measures.


Language(s): eng - English
 Dates: 2018-10-152018-05-182018-10-162018-10-242019-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.cyto.2018.10.012
PMID: 30539782
Other: Epub 2018
 Degree: -



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Project information

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Project name : -
Grant ID : 01EO1501
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : Obesity Mechanisms / SFB 1052
Grant ID : -
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 82DZD00601
Funding program : -
Funding organization : Deutsches Zentrum für Diabetesforschung

Source 1

Title: Cytokine
Source Genre: Journal
Publ. Info: London : Academic Press
Pages: - Volume / Issue: 113 Sequence Number: - Start / End Page: 400 - 404 Identifier: ISSN: 1043-4666
CoNE: https://pure.mpg.de/cone/journals/resource/954922650146