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  Dosage Compensation of the X Chromosome: A Complex Epigenetic Assignment Involving Chromatin Regulators and Long Noncoding RNAs

Samata, M., & Akhtar, A. (2018). Dosage Compensation of the X Chromosome: A Complex Epigenetic Assignment Involving Chromatin Regulators and Long Noncoding RNAs. Annual Review of Biochemistry, 87, 323-350. doi:10.1146/annurev-biochem-062917-011816.

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 Creators:
Samata, Maria1, Author
Akhtar, Asifa1, Author              
Affiliations:
1Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243643              

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Free keywords: dosage compensation, X chromosome, male-specific lethal, histone acetylation, H4K16ac, transcription, long noncoding RNAs
 Abstract: X chromosome regulation represents a prime example of an epigenetic phenomenon where coordinated regulation of a whole chromosome is required. In flies, this is achieved by transcriptional upregulation of X chromosomal genes in males to equalize the gene dosage differences in females. Chromatin-bound proteins and long noncoding RNAs (lncRNAs) constituting a ribonucleoprotein complex known as the male-specific lethal (MSL) complex or the dosage compensation complex mediate this process. MSL complex members decorate the male X chromosome, and their absence leads to male lethality. The male X chromosome is also enriched with histone H4 lysine 16 acetylation (H4K16ac), indicating that the chromatin compaction status of the X chromosome also plays an important role in transcriptional activation. How the X chromosome is specifically targeted and how dosage compensation is mechanistically achieved are central questions for the field. Here, we review recent advances, which reveal a complex interplay among lncRNAs, the chromatin landscape, transcription, and chromosome conformation that fine-tune X chromosome gene expression.

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Language(s): eng - English
 Dates: 2018-04-18
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Annual Review of Biochemistry
Source Genre: Journal
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Publ. Info: Palo Alto, Calif. : Stanford University Press
Pages: - Volume / Issue: 87 Sequence Number: - Start / End Page: 323 - 350 Identifier: ISSN: 0066-4154
CoNE: https://pure.mpg.de/cone/journals/resource/954925458038