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Zusammenfassung:
During navigation, hippocampal spatial maps are thought to interact with action-planning systems in other regions of cortex. We here report a key role for spike-time coordination in functional coupling of the medial prefrontal cortex (mPFC) to the hippocampus through th e thalamic nucleus reunies (NR). When rats perform a T-maze alternation task, spikes of neurons in mPFC and NR exhibit enhanced coordingation to the CA1 theta rhythm before the choice point on the maze. A similar coordination to CA1 theta was observed in neurons of the supramammilary nucleus (SUM). Optogenetic sliencing of SUM neurons reduced the temporal coordination in the mPFC-NR-CA1 circuit. Following SUM activation, trajectory reprsentations were impaired in both NR and CA1, but not in mPFC, indicating a failure in transmission of action plans from mPFC to the hippocampus. The findings identify theta-frequency spike-time coordination as a mechamism for gaing of information flow in the mPFC-NR-CA1 circuit.
