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  Learning-related plasticity in denrite-targetin layer 1 interneurons

Abs, E., Poorthuis, R., Apelblat, D., Muhammad, K., Pardi, B., Enke, L., et al. (2018). Learning-related plasticity in denrite-targetin layer 1 interneurons. Neuron. doi:10.1016/j.neuron.2018.09.001.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-74A4-2 Version Permalink: https://hdl.handle.net/21.11116/0000-0002-74A5-1
Genre: Journal Article

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 Creators:
Abs, E.1, Author
Poorthuis, R.B.1, Author
Apelblat, D.2, Author
Muhammad, K.1, Author
Pardi, B.1, Author
Enke, L.1, Author
Kushinsky, D.2, Author
Pu, D.L.1, Author
Eizinger, M.F.3, Author
Conzelmann, K.K.3, Author
Spiegel, I.4, Author
Letzkus, J.J.5, Author
Affiliations:
1Max Planck Instiitute for Brain Research, 60438 Frankfurt, Germany, ou_persistent22              
2Department of Neurobiology, Weizman Institute of Science, 76100 Rehovot, Israel, ou_persistent22              
3Max von Pettenkofer Institute, Virology, Medical Faculty and Gene Center, Ludwig Maxilmilians Universiy, 81377 Munich, Germany, ou_persistent22              
4Department of Neurobiology, Weizman Institute of Science, 76100 Rehovot, Israel electronic address: ivo.spiegel@weizman.ac.il, ou_persistent22              
5Max Planck Institute for Brain Research, 60438 Frankfurt, Germany electronic address: johannes.letzkus@brain.mpg.de, ou_persistent22              

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Free keywords: GABAergic interneurons; NDNF interneurons; connectivity; dendritic inhibition; fear learning; genetic markers; interneurons; layer 1; neocortical circuits; somatostatin interneurons; top-down processing
 Abstract: A wealth of data has elucidated the mechasms by which sensory inputs are encoded in the neocortex, but how these processes are regulated by the behavioral relevance of sensory information is less understood. Here, we focus on neocortical layer 1 (L1), a key location for processing of such top-down information. Using Neuron-Derived Neotrophic Factor (NDNF) as a selective marker of L1 interneurons (INs) and in vivo 2-photon calcium imaging, electrophysiology, viral tracing, optogenetics, and associative memory, we find that L1 NDNF-INs mediate a prolonged form of inhbitionin distal pyramidal neuron dendrites that correlates with the strength of the memory trace. Conversely, inhibition from Martinotti cells remains unchanged after conditioning but in turn tightly controls sensory responses in NDNF-INs. These results define a genetically addressable form of dendritic inhibition that is highly experience dependent and indicate that in addition to disinibition, salient stimuli are encoded at elevated levels of distal dendritic inhibition.

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Language(s): eng - English
 Dates: 2018-09-15
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuron.2018.09.001
PMID: 30269988
PII: S0896-6273(18)3077-8
 Degree: -

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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565