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  Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs

Noori, H., Mervin, L., Bokharaie, V., Durmus, Ö., Egenrieder, L., Fritze, S., et al. (2018). Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs. Nature Communications, 9: 4699, pp. 1-14. doi:10.1038/s41467-018-07239-1.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-7557-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-7558-8
Genre: Journal Article

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 Creators:
Noori, HR1, 2, Author              
Mervin, LH, Author
Bokharaie, V1, 2, Author              
Durmus, Ö, Author
Egenrieder , L, Author
Fritze, S, Author
Gruhlke, B, Author
Reinhardt, G, Author
Schabel, H-H, Author
Staudenmaier, S, Author
Logothetis, NK2, 3, Author              
Bender, A, Author
Spanagel, R, Author
Affiliations:
1Research Group Neuronal Convergence, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528694              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: Neuropsychiatric disorders are the third leading cause of global disease burden. Current pharmacological treatment for these disorders is inadequate, with often insufficient efficacy and undesirable side effects. One reason for this is that the links between molecular drug action and neurobehavioral drug effects are elusive. We use a big data approach from the neurotransmitter response patterns of 258 different neuropsychiatric drugs in rats to address this question. Data from experiments comprising 110,674 rats are presented in the Syphad database [www.syphad.org]. Chemoinformatics analyses of the neurotransmitter responses suggest a mismatch between the current classification of neuropsychiatric drugs and spatiotemporal neurostransmitter response patterns at the systems level. In contrast, predicted drug–target interactions reflect more appropriately brain region related neurotransmitter response. In conclusion the neurobiological mechanism of neuropsychiatric drugs are not well reflected by their current classification or their chemical similarity, but can be better captured by molecular drug–target interactions.

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 Dates: 2018-102018-11
 Publication Status: Published online
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.1038/s41467-018-07239-1
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 9 Sequence Number: 4699 Start / End Page: 1 - 14 Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723