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  The contribution of mesiofrontal cortex to the preparation and execution of repetitive syllable productions: an fMRI study

Brendel, B., Hertrich, I., Erb, M., Lindner, A., Riecker, A., Grodd, W., et al. (2010). The contribution of mesiofrontal cortex to the preparation and execution of repetitive syllable productions: an fMRI study. NeuroImage, 50(3), 1219-1230. doi:10.1016/j.neuroimage.2010.01.039.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-771E-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-771F-7
Genre: Journal Article

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Brendel, B, Author
Hertrich, I, Author
Erb, M1, Author              
Lindner, A, Author
Riecker, A, Author
Grodd, W1, Author              
Ackermann, H, Author
Affiliations:
1University of Tübingen, ou_persistent22              

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 Abstract: Clinical data indicate that the brain network of speech motor control can be subdivided into at least three functional–neuroanatomical subsystems: (i) planning of movement sequences (premotor ventrolateral–frontal cortex and/or anterior insula), (ii) preparedness for/initiation of upcoming verbal utterances (supplementary motor area, SMA), and (iii) on-line innervation of vocal tract muscles, i.e., motor execution (corticobulbar system, basal ganglia, cerebellum). Using an event-related design, this functional magnetic resonance imaging (fMRI) study sought to further delineate the contribution of SMA to pre-articulatory processes of speech production (preceding the innervation of vocal tract muscles) during an acoustically paced syllable repetition task forewarned by a tone signal. Hemodynamic activation across the whole brain and the time courses of the responses in five regions of interest (ROIs) were computed. First, motor preparation was associated with a widespread bilateral activation pattern, encompassing brainstem structures, SMA, insula, premotor ventrolateral–frontal areas, primary sensorimotor cortex (SMC), basal ganglia, and the superior cerebellum. Second, calculation of the time courses of BOLD (“blood oxygenation level-dependent”) signal changes revealed the warning stimulus to elicit synchronous onset of hemodynamic activation in these areas. However, during 4-s intervals of syllable repetitions SMA and cerebellum showed opposite temporal activation patterns in terms of a shorter (SMA) and longer (cerebellum) latency of the entire BOLD response—as compared to SMC, indicating different pacing mechanisms during the initial and the ongoing phase of the task. Nevertheless, the contribution of SMA was not exclusively restricted to the preparation/initiation of verbal responses since the extension of mesiofrontal activation varied with task duration.

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 Dates: 2010-04
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2010.01.039
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 50 (3) Sequence Number: - Start / End Page: 1219 - 1230 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166