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  Identification and directed development of non-organic catalysts with apparent pan-enzymatic mimicry into nanozymes for efficient prodrug conversion

Walther, R., Winther, A. K., Fruergaard, A. S., van den Akker, W., Sørensen, L., Nielsen, S. M., et al. (2019). Identification and directed development of non-organic catalysts with apparent pan-enzymatic mimicry into nanozymes for efficient prodrug conversion. Angewandte Chemie International Edition, 58(1), 278-282. doi:10.1002/anie.201812668.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-7A8F-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-C56E-5
Genre: Journal Article

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 Creators:
Walther, Raoul, Author
Winther, Anna K., Author
Fruergaard, Anne Sofie, Author
van den Akker, Wouter, Author
Sørensen, Lise, Author
Nielsen, Signe Maria, Author
Jarlstad Olesen, Morten T., Author
Dai, Yitao, Author
Jeppesen, Henrik S., Author
Lamagni, Paolo, Author
Savateev, Aleksandr1, Author              
Pedersen, Søren Lykke, Author
Frich, Camilla Kaas, Author
Vigier‐Carrière, Cécile, Author
Lock, Dr. Nina, Author
Singh, Mandeep, Author
Bansal, Prof. Vipul, Author
Meyer, Dr. Rikke L., Author
Zelikin, Dr. Alexander N., Author
Affiliations:
1Aleksandr Savateev, Kolloidchemie, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2421702              

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Free keywords: nanozyme, glucuronide, enzyme-prodrug therapy, prodrug, enzyme mimicry
 Abstract: Nanozymes, nanoparticles that mimic the natural activity of enzymes, are intriguing academically and are important in the context of Origin of Life. However, current nanozymes offer mimicry to a narrow range of mammalian enzymes, near-exclusively performing redox reactions. In this work, we present an unexpected discovery of non-proteinaceous enzymes based on metals, metal oxides, 1D/2D-materials, and non-metallic nanomaterials. Specific novelty of our findings lies in the identification of nanozymes with apparent mimicry of diverse mammalian enzymes, including unique pan-glycosidases. Further novelty lies in the identification of the substrate scope for the lead candidates, specifically in the context of bioconversion of glucuronides, that is, human metabolites and privileged prodrugs in the field of enzyme-prodrug therapies. Lastly, nanozymes are employed for conversion of glucuronide prodrugs into marketed anti-inflammatory and antibacterial agents, as well as ?nanozyme prodrug therapy? to mediate antibacterial measures.

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Language(s): eng - English
 Dates: 2018-11-082019
 Publication Status: Published in print
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Title: Angewandte Chemie International Edition
  Other : Angewandte Chemie, International Edition
  Other : Angew. Chem. Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 58 (1) Sequence Number: - Start / End Page: 278 - 282 Identifier: ISSN: 1433-7851

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Title: Angewandte Chemie
  Abbreviation : Angew. Chem.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 131 (1) Sequence Number: - Start / End Page: 284 - 288 Identifier: ISSN: 0044-8249