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  Subtype-specific regulatory network rewiring in acute myeloid leukemia

Assi, S. A., Imperato, M. R., Coleman, D. J. L., Pickin, A., Potluri, S., Ptasinska, A., et al. (2019). Subtype-specific regulatory network rewiring in acute myeloid leukemia. Nature Genetics, 51, 151-162. doi:10.1038/s41588-018-0270-1.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-C2CC-D Version Permalink: http://hdl.handle.net/21.11116/0000-0004-DA9D-6
Genre: Journal Article

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 Creators:
Assi, Salam A.1, Author
Imperato, Maria Rosaria1, Author
Coleman, Daniel J. L.1, Author
Pickin, Anna1, Author
Potluri, Sandeep1, Author
Ptasinska, Anetta1, Author
Chin, Paulynn Suyin1, Author
Blair, Helen1, Author
Cauchy, Pierre2, Author              
James, Sally R.1, Author
Zacarias-Cabeza, Joaquin1, Author
Gilding, L. Niall1, Author
Beggs, Andrew1, Author
Clokie, Sam1, Author
Loke, Justin C.1, Author
Jenkin, Phil1, Author
Uddin, Ash1, Author
Delwel, Ruud1, Author
Richards, Stephen J.1, Author
Raghavan, Manoj1, Author
Griffiths, Michael J.1, AuthorHeidenreich, Olaf1, AuthorCockerill, Peter N. 1, AuthorBonifer, Constanze1, Author more..
Affiliations:
1External Organizations, ou_persistent22              
2Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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 Abstract: Acute myeloid leukemia (AML) is a heterogeneous disease caused by a variety of alterations in transcription factors, epigenetic regulators and signaling molecules. To determine how different mutant regulators establish AML subtype-specific transcriptional networks, we performed a comprehensive global analysis of cis-regulatory element activity and interaction, transcription factor occupancy and gene expression patterns in purified leukemic blast cells. Here, we focused on specific subgroups of subjects carrying mutations in genes encoding transcription factors (RUNX1, CEBPα), signaling molecules (FTL3-ITD, RAS) and the nuclear protein NPM1). Integrated analysis of these data demonstrates that each mutant regulator establishes a specific transcriptional and signaling network unrelated to that seen in normal cells, sustaining the expression of unique sets of genes required for AML growth and maintenance.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41588-018-0270-1
 Degree: -

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Title: Nature Genetics
  Other : Nature Genet.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Nature America, Inc.
Pages: - Volume / Issue: 51 Sequence Number: - Start / End Page: 151 - 162 Identifier: ISSN: 1061-4036
CoNE: https://pure.mpg.de/cone/journals/resource/954925598609