English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Mapping the MHC class I spliced immunopeptidome of cancer cells.

Liepe, J., Sidney, J., Lorenz, F. K. M., Sette, A., & Mishto, M. (2019). Mapping the MHC class I spliced immunopeptidome of cancer cells. Cancer Immunology Research, 7(1), 62-76. doi:10.1158/2326-6066.CIR-18-0424.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0002-7DFD-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-B97C-3
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Liepe, J.1, Author              
Sidney, J., Author
Lorenz, F. K. M., Author
Sette, A., Author
Mishto, M., Author
Affiliations:
1Research Group of Quantitative and System Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_2466694              

Content

show
hide
Free keywords: -
 Abstract: Anti-cancer immunotherapies demand optimal epitope targets, which could include proteasome-generated spliced peptides if tumor cells were to present them. Here, we show that spliced peptides are widely presented by MHC class I molecules of colon and breast carcinoma cell lines. The peptides derive from hot spots within antigens and enlarge the antigen coverage. Spliced peptides also represent a large number of antigens that would otherwise be neglected by patrolling T cells. These antigens tend to be long, hydrophobic, and basic. Thus, spliced peptides can be a key to identifying targets in an enlarged pool of antigens associated with cancer.

Details

show
hide
Language(s): eng - English
 Dates: 2018-11-132019-01-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1158/2326-6066.CIR-18-0424
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cancer Immunology Research
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 7 (1) Sequence Number: - Start / End Page: 62 - 76 Identifier: -