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  Salivary cortisone, as a biomarker for psychosocial stress, is associated with state anxiety and heart rate

Bae, Y. J., Reinelt, J., Netto, J., Uhlig, M., Willenberg, A., Ceglarek, U., et al. (2019). Salivary cortisone, as a biomarker for psychosocial stress, is associated with state anxiety and heart rate. Psychoneuroendocrinology, 101, 35-41. doi:10.1016/j.psyneuen.2018.10.015.

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 Urheber:
Bae, Yoon Ju1, Autor
Reinelt, Janis2, Autor           
Netto, Jeffrey1, Autor
Uhlig, Marie2, Autor           
Willenberg, Anja1, Autor
Ceglarek, Uta1, Autor
Villringer, Arno2, 3, Autor           
Thiery, Joachim1, Autor
Gaebler, Michael2, 3, 4, Autor           
Kratzsch, Juergen1, Autor
Affiliations:
1Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
4Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

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Schlagwörter: Temporal dynamics; Stress biomarker; Salivary cortisone; Trier Social Stress Test; State trait anxiety inventory; Heart rate
 Zusammenfassung: Background
Stress activates the central nervous, the autonomic nervous, and the endocrine system. This study aimed to (1) test the usability of salivary cortisone in a standardized psychosocial stressor, (2) create a comprehensive profile of hormonal responses to determine laboratory parameters with high discriminatory power, and (3) analyze their association with psychometric and autonomic stress measures.
Methods
Healthy young men (18–35 years) completed either the Trier Social Stress Test (TSST) (n = 33) or a Placebo-TSST (n = 34). Blood and saliva were collected at 14 time points along with state-anxiety (STAI) and heart rate. Serum steroids (cortisol*, cortisone*, dehydroepiandrosterone-sulfate, androstenedione*, progesterone*, 17-hydroxyprogesterone*, testosterone, estradiol*, aldosterone*), salivary cortisol* and cortisone*, copeptin*, adrenocorticoptropic hormone*, corticosteroid-binding globulin, and salivary alpha-amylase* were analyzed. We used mixed-design ANOVAs to test group differences, receiver operator characteristic (ROC) curve analyses to assess the discriminatory power of each measure, and Spearman correlation analyses to probe the association between measures.
Results
The largest area under the ROC curve was observed in salivary cortisone at 20 min after the end of the TSST (AUC = 0.909 ± 0.044, p < 0.0001). Significant time-by-group interactions were found in the parameters marked with * above, indicating stress-induced increases. The peak response of salivary cortisone was significantly associated with those of STAI (rho = 0.477, p = 0.016) and heart rate (rho = 0.699, p < 0.0001) in the TSST group.
Conclusion
Our study found salivary cortisone to be a stress biomarker with high discriminatory power and significant correlations with subjective and autonomic stress measures. Our results can inform future stress studies of sampling time for different laboratory parameters.

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Sprache(n): eng - English
 Datum: 2018-09-252018-08-092018-10-182018-10-282019-03
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.psyneuen.2018.10.015
PMID: 30408721
Anderer: Epub ahead of print
 Art des Abschluß: -

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Titel: Psychoneuroendocrinology
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Oxford : Pergamon
Seiten: - Band / Heft: 101 Artikelnummer: - Start- / Endseite: 35 - 41 Identifikator: ISSN: 0306-4530
CoNE: https://pure.mpg.de/cone/journals/resource/954925514499