English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Chiral cilia orientation in the left-right organizer

Ferreira, R. R., Pakula, G., Klaeyle, L., Fukui, H., Vilfan, A., Supatto, W., et al. (2018). Chiral cilia orientation in the left-right organizer. Cell Reports, 25(8), 2008-2016. doi:10.1016/j.celrep.2018.10.069.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0002-8679-F Version Permalink: http://hdl.handle.net/21.11116/0000-0002-867A-E
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Ferreira, R. R., Author
Pakula, G., Author
Klaeyle, L., Author
Fukui, H., Author
Vilfan, Andrej1, Author              
Supatto, W., Author
Vermot, J., Author
Affiliations:
1Department of Living Matter Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2570692              

Content

show
hide
Free keywords: Danio rerio; Dnaaf1/Lrrc50; PKD2/PC2/TRPP2/polycistin-2; Rock2B; blebbistatin; lrdr1; nodal; spaw; tissue asymmetry; trilobite/Vangl2
 Abstract: Chirality is a property of asymmetry between an object and its mirror image. Most biomolecules and many cell types are chiral. In the left-right organizer (LRO), cilia-driven flows transfer such chirality to the body scale. However, the existence of cellular chirality within tissues remains unknown. Here, we investigate this question in Kupffer's vesicle (KV), the zebrafish LRO. Quantitative live imaging reveals that cilia populating the KV display asymmetric orientation between the right and left sides, resulting in a chiral structure, which is different from the chiral cilia rotation. This KV chirality establishment is dynamic and depends on planar cell polarity. While its impact on left-right (LR) symmetry breaking remains unclear, we show that this asymmetry does not depend on the LR signaling pathway or flow. This work identifies a different type of tissue asymmetry and sheds light on chirality genesis in developing tissues.

Details

show
hide
Language(s): eng - English
 Dates: 2018-11-20
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.celrep.2018.10.069
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cell Reports
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 25 (8) Sequence Number: - Start / End Page: 2008 - 2016 Identifier: -