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  Functions of actin in mouse oocytes at a glance

Uraji, J., Scheffler, K., & Schuh, M. (2018). Functions of actin in mouse oocytes at a glance. Journal of Cell Science, 131(22): 218099. doi:10.1242/jcs.218099.

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 Creators:
Uraji, J.1, Author           
Scheffler, K.1, Author           
Schuh, M.1, Author           
Affiliations:
1Department of Meiosis, MPI for Biophysical Chemistry, Max Planck Society, ou_2205654              

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Free keywords: Meiosis, Oocyte, Spindle, Actin, Cytoskeleton, Chromosomes
 Abstract: Gametes undergo a specialized and reductional cell division termed meiosis. Female gametes (oocytes) undergo two rounds of meiosis; the first meiotic division produces the fertilizable egg, while the second meiotic division occurs upon fertilization. Both meiotic divisions are highly asymmetric, producing a large egg and small polar bodies. Actin takes over various essential function during oocyte meiosis, many of which commonly rely on microtubules in mitotic cells. Specifically, the actin network has been linked to long-range vesicle transport, nuclear positioning, spindle migration and anchorage, polar body extrusion and accurate chromosome segregation in mammalian oocytes. In this Cell Science at a Glance article and the accompanying poster, we summarize the many functions of the actin cytoskeleton in oocytes, with a focus on findings from the mouse model system.

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Language(s): eng - English
 Dates: 2018-11-222018-11
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1242/jcs.218099
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Title: Journal of Cell Science
Source Genre: Journal
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Publ. Info: Cambridge, U.K. : Co. of Biologists
Pages: 6 Volume / Issue: 131 (22) Sequence Number: 218099 Start / End Page: - Identifier: ISSN: 0021-9533
CoNE: https://pure.mpg.de/cone/journals/resource/954925326678