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  Functions of actin in mouse oocytes at a glance.

Uraji, J., Scheffler, K., & Schuh, M. (2018). Functions of actin in mouse oocytes at a glance. Journal of Cell Science, 131(22): 218099. doi:10.1242/jcs.218099.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-8AB4-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-BCFB-F
Genre: Journal Article

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 Creators:
Uraji, J.1, Author              
Scheffler, K.1, Author              
Schuh, M.1, Author              
Affiliations:
1Department of Meiosis, MPI for Biophysical Chemistry, Max Planck Society, ou_2205654              

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Free keywords: Meiosis, Oocyte, Spindle, Actin, Cytoskeleton, Chromosomes
 Abstract: Gametes undergo a specialized and reductional cell division termed meiosis. Female gametes (oocytes) undergo two rounds of meiosis; the first meiotic division produces the fertilizable egg, while the second meiotic division occurs upon fertilization. Both meiotic divisions are highly asymmetric, producing a large egg and small polar bodies. Actin takes over various essential function during oocyte meiosis, many of which commonly rely on microtubules in mitotic cells. Specifically, the actin network has been linked to long-range vesicle transport, nuclear positioning, spindle migration and anchorage, polar body extrusion and accurate chromosome segregation in mammalian oocytes. In this Cell Science at a Glance article and the accompanying poster, we summarize the many functions of the actin cytoskeleton in oocytes, with a focus on findings from the mouse model system.

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Language(s): eng - English
 Dates: 2018-11-222018-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1242/jcs.218099
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Title: Journal of Cell Science
Source Genre: Journal
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Pages: 6 Volume / Issue: 131 (22) Sequence Number: 218099 Start / End Page: - Identifier: -