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  Cued reactivation during slow-wave sleep induces brain connectivity changes related to memory stabilization

Berkers, R., Ekman, M., van Dongen, E. V., Takashima, A., Barth, M., Paller, K. A., et al. (2018). Cued reactivation during slow-wave sleep induces brain connectivity changes related to memory stabilization. Scientific Reports, 8: 16958. doi:10.1038/s41598-018-35287-6.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-91C4-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-A39F-2
Genre: Journal Article

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 Creators:
Berkers, Ruud1, 2, Author              
Ekman, Matthias2, Author
van Dongen, Eelco. V. 2, Author
Takashima, Atsuko 2, 3, Author
Barth, Markus 2, 4, Author
Paller, Ken A. 5, Author
Fernández, Guillén 2, Author
Affiliations:
1Max Planck Research Group Adaptive Memory, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2295691              
2Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
3Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands, ou_persistent22              
4Centre for Advanced Imaging (CAI), University of Queensland, Brisbane, Australia, ou_persistent22              
5Northwestern University, Evanston, IL, USA, ou_persistent22              

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Free keywords: Auditory stimulation; Brain region; Controlled study; Hippocampus; Information retrieval; Medial prefrontal cortex; Memory; Occipital cortex; Parahippocampal gyrus; Slow wave sleep; Thalamus
 Abstract: Memory reprocessing following acquisition enhances memory consolidation. Specifically, neural activity during encoding is thought to be ‘replayed’ during subsequent slow-wave sleep. Such memory replay is thought to contribute to the functional reorganization of neural memory traces. In particular, memory replay may facilitate the exchange of information across brain regions by inducing a reconfiguration of connectivity across the brain. Memory reactivation can be induced by external cues through a procedure known as “targeted memory reactivation”. Here, we analysed data from a published study with auditory cues used to reactivate visual object-location memories during slow-wave sleep. We characterized effects of memory reactivation on brain network connectivity using graph-theory. We found that cue presentation during slow-wave sleep increased global network integration of occipital cortex, a visual region that was also active during retrieval of object locations. Although cueing did not have an overall beneficial effect on the retention of cued versus uncued associations, individual differences in overnight memory stabilization were related to enhanced network integration of occipital cortex. Furthermore, occipital cortex displayed enhanced connectivity with mnemonic regions, namely the hippocampus, parahippocampal gyrus, thalamus and medial prefrontal cortex during cue sound presentation. Together, these results suggest a neural mechanism where cue-induced replay during sleep increases integration of task-relevant perceptual regions with mnemonic regions. This cross-regional integration may be instrumental for the consolidation and long-term storage of enduring memories.

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Language(s): eng - English
 Dates: 2018-01-192018-11-012018-11-16
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41598-018-35287-6
PMID: 30446718
PMC: PMC6240046
 Degree: -

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Project name : The neurobiology of schemas: knowledge acquisition and consolidation / NEUROSCHEMA
Grant ID : 268800
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Language in Interaction
Grant ID : -
Funding program : -
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : 400-06-110
Funding program : -
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : 451-06-006
Funding program : -
Funding organization : Netherlands Organisation for Scientific Research (NWO)

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 8 Sequence Number: 16958 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322