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  Melody processing characterizes functional neuroanatomy in the aging brain

Agustus, J. L., Golden, H. L., Callaghan, M. F., Bond, R. L., Benhamou, E., Hailstone, J. C., et al. (2018). Melody processing characterizes functional neuroanatomy in the aging brain. Frontiers in Neuroscience, 12: 815. doi:10.3389/fnins.2018.00815.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-92A8-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9DD9-8
Genre: Journal Article

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 Creators:
Agustus, Jennifer L. 1, Author
Golden, Hannah L. 1, Author
Callaghan, Martina F. 2, Author
Bond, Rebecca L. 1, Author
Benhamou, Elia 1, Author
Hailstone, Julia C. 1, Author
Weiskopf, Nikolaus3, Author              
Warren, Jason D. 1, Author
Affiliations:
1Dementia Research Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
2Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
3Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Free keywords: Aging; Complex sound; fMRI; Music; Semantic; Temporal
 Abstract: The functional neuroanatomical mechanisms underpinning cognition in the normal older brain remain poorly defined, but have important implications for understanding the neurobiology of aging and the impact of neurodegenerative diseases. Auditory processing is an attractive model system for addressing these issues. Here, we used fMRI of melody processing to investigate auditory pattern processing in normal older individuals. We manipulated the temporal (rhythmic) structure and familiarity of melodies in a passive listening, ‘sparse’ fMRI protocol. A distributed cortico-subcortical network was activated by auditory stimulation compared with silence; and within this network, we identified separable signatures of anisochrony processing in bilateral posterior superior temporal lobes; melodic familiarity in bilateral anterior temporal and inferior frontal cortices; and melodic novelty in bilateral temporal and left parietal cortices. Left planum temporale emerged as a ‘hub’ region functionally partitioned for processing different melody dimensions. Activation of Heschl’s gyrus by auditory stimulation correlated with the integrity of underlying cortical tissue architecture, measured using multi-parameter mapping. Our findings delineate neural substrates for analyzing perceptual and semantic properties of melodies in normal aging. Melody (auditory pattern) processing may be a useful candidate paradigm for assessing cerebral networks in the older brain and potentially, in neurodegenerative diseases of later life.

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Language(s): eng - English
 Dates: 2017-12-042018-10-192018-11-19
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnins.2018.00815
PMID: 30524219
PMC: PMC6262413
Other: eCollection 2018
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Funding organization : Alzheimer’s Research UK
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Funding organization : Brain Research UK
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Funding organization : Wolfson Foundation
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Funding organization : Wellcome Trust
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Funding organization : Medical Research Council (MRC)
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Funding organization : Alzheimer’s Society
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Funding organization : NIHR UCLH Biomedical Research Centre
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Grant ID : 091593/Z/10/Z
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Funding organization : Wellcome Trust
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Funding program : Alzheimer Research UK Ph.D. Fellowship
Funding organization : Alzheimer’s Research UK
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Grant ID : 091673/Z/10/Z
Funding program : Wellcome Trust Senior Clinical Research Fellowship
Funding organization : Wellcome Trust

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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 12 Sequence Number: 815 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548