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  Extraordinary genome instability and widespread chromosome rearrangements during vegetative growth

Möller, M., Habig, M., Freitag, M., & Stukenbrock, E. H. (2018). Extraordinary genome instability and widespread chromosome rearrangements during vegetative growth. Genetics, 210(2), 517-529. doi:10.1534/genetics.118.301050.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-9479-F Version Permalink: http://hdl.handle.net/21.11116/0000-0002-947A-E
Genre: Journal Article

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Möller, Mareike1, Author              
Habig, Michael1, Author              
Freitag, Michael, Author
Stukenbrock, Eva H.1, Author              
Affiliations:
1Max Planck Fellow Group Environmental Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2068284              

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Free keywords: chromosome loss; mitosis; fungal pathogen; experiemental evolution
 Abstract: The haploid genome of the pathogenic fungus Zymoseptoria tritici is contained on “core” and “accessory” chromosomes. While 13 core chromosomes are found in all strains, as many as eight accessory chromosomes show presence/absence variation and rearrangements among field isolates. The factors influencing these presence/absence polymorphisms are so far unknown. We investigated chromosome stability using experimental evolution, karyotyping, and genome sequencing. We report extremely high and variable rates of accessory chromosome loss during mitotic propagation in vitro and in planta. Spontaneous chromosome loss was observed in 2 to >50% of cells during 4 weeks of incubation. Similar rates of chromosome loss in the closely related Zymoseptoria ardabiliae suggest that this extreme chromosome dynamic is a conserved phenomenon in the genus. Elevating the incubation temperature greatly increases instability of accessory and even core chromosomes, causing severe rearrangements involving telomere fusion and chromosome breakage. Chromosome losses do not affect the fitness of Zymoseptoria tritici in vitro, but some lead to increased virulence, suggesting an adaptive role of this extraordinary chromosome instability.

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Language(s): eng - English
 Dates: 2018-04-192018-07-182018-10-042018-10
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1534/genetics.118.301050
BibTex Citekey: M{\"o}ller517
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Title: Genetics
Source Genre: Journal
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Publ. Info: Genetics Society of America
Pages: - Volume / Issue: 210 (2) Sequence Number: - Start / End Page: 517 - 529 Identifier: ISSN: 0016-6731
CoNE: https://pure.mpg.de/cone/journals/resource/954925400554