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  Comparative genomics of the major parasitic worms

Coghlan, A., Tyagi, R., Cotton, J. A., Holroyd, N., Rosa, B. A., Tsai, I. J., et al. (2018). Comparative genomics of the major parasitic worms. Nature Genetics, 51, 163-174. doi:10.1038/s41588-018-0262-1.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-94C4-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-F47B-0
Genre: Journal Article

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Coghlan, Avril, Author
Tyagi, Rahul, Author
Cotton, James A., Author
Holroyd, Nancy, Author
Rosa, Bruce A., Author
Tsai, Isheng Jason, Author
Laetsch, Dominik R., Author
Beech, Robin N., Author
Day, Tim A., Author
Hallsworth-Pepin, Kymberlie, Author
Ke, Huei-Mien, Author
Kuo, Tzu-Hao, Author
Lee, Tracy J., Author
Martin, John, Author
Maizels, Rick M., Author
Mutowo, Prudence, Author
Ozersky, Philip, Author
Parkinson, John, Author
Reid, Adam J., Author
Rawlings, Neil D., Author
Ribeiro, Diogo M., AuthorSwapna, Lakshmipuram Seshadri, AuthorStanley, Eleanor, AuthorTaylor, David W., AuthorWheeler, Nicolas J., AuthorZamanian, Mostafa, AuthorZhang, Xu1, 2, Author              Allan, Fiona, AuthorAllen, Judith E., AuthorAsano, Kazuhito, AuthorBabayan, Simon A., AuthorBah, Germanus, AuthorBeasley, Helen, AuthorBennett, Hayley M., AuthorBisset, Stewart A., AuthorCastillo, Estela, AuthorCook, Joseph, AuthorCooper, Philip J., AuthorCruz-Bustos, Teresa, AuthorCuéllar, Carmen, AuthorDevaney, Eileen, AuthorDoyle, Stephen R., AuthorEberhard, Mark L., AuthorEmery, Aidan, AuthorEom, Keeseon S., AuthorGilleard, John S., AuthorGordon, Daria, AuthorHarcus, Yvonne, AuthorHarsha, Bhavana, AuthorHawdon, John M., AuthorHill, Dolores E., AuthorHodgkinson, Jane, AuthorHorák, Petr, AuthorHowe, Kevin L., AuthorHuckvale, Thomas, AuthorKalbe, Martin3, 4, Author              Kaur, Gaganjot, AuthorKikuchi, Taisei, AuthorKoutsovoulos, Georgios, AuthorKumar, Sujai, AuthorLeach, Andrew R., AuthorLomax, Jane, AuthorMakepeace, Benjamin, AuthorMatthews, Jacqueline B., AuthorMuro, Antonio, AuthorO’Boyle, Noel Michael, AuthorOlson, Peter D., AuthorOsuna, Antonio, AuthorPartono, Felix, AuthorPfarr, Kenneth, AuthorRinaldi, Gabriel, AuthorForonda, Pilar, AuthorRollinson, David, AuthorSamblas, Mercedes Gomez, AuthorSato, Hiroshi, AuthorSchnyder, Manuela, AuthorScholz, Tomáš, AuthorShafie, Myriam, AuthorTanya, Vincent N., AuthorToledo, Rafael, AuthorTracey, Alan, AuthorUrban, Joseph F., AuthorWang, Lian-Chen, AuthorZarlenga, Dante, AuthorBlaxter, Mark L., AuthorMitreva, Makedonka, AuthorBerriman, Matthew, AuthorConsortium, International Helminth Genomes, Author more..
Affiliations:
1Alloy Design and Thermomechanical Processing, Microstructure Physics and Alloy Design, Max-Planck-Institut für Eisenforschung GmbH, Max Planck Society, ou_1863383              
2High-Entropy Alloys, Microstructure Physics and Alloy Design, Max-Planck-Institut für Eisenforschung GmbH, Max Planck Society, ou_3010672              
3Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              
4Research Group Parasitology, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445643              

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 Abstract: Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report a broad comparative study of 81 genomes of parasitic and non-parasitic worms. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritized new potential drug targets and compounds for testing. This comparative genomics resource provides a much-needed boost for the research community to understand and combat parasitic worms.

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Language(s): eng - English
 Dates: 2018-05-172018-09-242018-11-052018
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/s41588-018-0262-1
 Degree: -

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Title: Nature Genetics
  Other : Nature Genet.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America, Inc.
Pages: - Volume / Issue: 51 Sequence Number: - Start / End Page: 163 - 174 Identifier: ISSN: 1061-4036
CoNE: https://pure.mpg.de/cone/journals/resource/954925598609