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  Benefits of pallidal stimulation in dystonia are linked to cerebellar volume and cortical inhibition

Fečíková, A., Jech, R., Čejka, V., Čapek, V., Šťastná, D., Štětkářová, I., Mueller, K., Schroeter, M. L., & Růžička, F. (2018). Benefits of pallidal stimulation in dystonia are linked to cerebellar volume and cortical inhibition. Scientific Reports, 8:. doi:10.1038/s41598-018-34880-z.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0002-9714-D 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0003-996B-9
資料種別: 学術論文

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Fecikova_2018.pdf (出版社版), 2MB
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https://hdl.handle.net/21.11116/0000-0002-9716-B
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Fecikova_2018.pdf
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作成者

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 作成者:
Fečíková, Anna 1, 著者
Jech, Robert 1, 著者
Čejka, Václav1, 2, 著者
Čapek, Václav1, 著者
Šťastná, Daniela 3, 著者
Štětkářová, Ivana 4, 著者
Mueller, Karsten5, 著者           
Schroeter, Matthias L.6, 7, 著者           
Růžička, Filip 1, 著者
所属:
1Department of Neurology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ou_persistent22              
2Faculty of Biomedical Engineering, Czech Technical University, Prague, Czech Republic, ou_persistent22              
3Department of Neurosurgery, Na Homolce Hospital, Prague, Czech Republic, ou_persistent22              
4Department of Neurology, Third Faculty of Medicine, Charles University, Prague, Czech Republic, ou_persistent22              
5Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
6Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
7Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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 要旨: Clinical benefits of pallidal deep brain stimulation (GPi DBS) in dystonia increase relatively slowly suggesting slow plastic processes in the motor network. Twenty-two patients with dystonia of various distribution and etiology treated by chronic GPi DBS and 22 healthy subjects were examined for short-latency intracortical inhibition of the motor cortex elicited by paired transcranial magnetic stimulation. The relationships between grey matter volume and intracortical inhibition considering the long-term clinical outcome and states of the GPi DBS were analysed. The acute effects of GPi DBS were associated with a shortening of the motor response whereas the grey matter of chronically treated patients with a better clinical outcome showed hypertrophy of the supplementary motor area and cerebellar vermis. In addition, the volume of the cerebellar hemispheres of patients correlated with the improvement of intracortical inhibition which was generally less effective in patients than in controls regardless of the DBS states. Importantly, good responders to GPi DBS showed a similar level of short-latency intracortical inhibition in the motor cortex as healthy controls whereas non-responders were unable to increase it. All these results support the multilevel impact of effective DBS on the motor networks in dystonia and suggest potential biomarkers of responsiveness to this treatment.

資料詳細

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言語: eng - English
 日付: 2018-01-252018-10-262018-11-21
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1038/s41598-018-34880-z
PMID: 30464181
PMC: PMC6249276
 学位: -

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Project information

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Project name : -
Grant ID : IGA MZ ČR NT 12282
Funding program : -
Funding organization : Czech Ministry of Health
Project name : -
Grant ID : 16-13323 S
Funding program : -
Funding organization : Czech Science Foundation GAČR
Project name : Czech Republic Progres Q27/LF1
Grant ID : -
Funding program : -
Funding organization : Charles University
Project name : -
Grant ID : PDF-IRG-1307
Funding program : -
Funding organization : Parkinson’s Disease Foundation
Project name : -
Grant ID : MJFF-11362
Funding program : -
Funding organization : Michael J. Fox Foundation

出版物 1

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出版物名: Scientific Reports
  省略形 : Sci. Rep.
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: London, UK : Nature Publishing Group
ページ: - 巻号: 8 通巻号: 17218 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322