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  Orbitofrontal lesion alters brain dynamics of emotion-attention and emotion-cognitive control interaction in humans

Kuusinen, V., Cesnaite, E., Peräkylä, J., Ogawa, K. H., & Hartikainen, K. M. (2018). Orbitofrontal lesion alters brain dynamics of emotion-attention and emotion-cognitive control interaction in humans. Frontiers in Human Neuroscience, 12: 437. doi:10.3389/fnhum.2018.00437.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-975A-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-995F-7
Genre: Journal Article

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 Creators:
Kuusinen, Venla 1, 2, Author
Cesnaite, Elena1, 3, Author              
Peräkylä, Jari 1, 2, Author
Ogawa, Keith H. 4, Author
Hartikainen, Kaisa M. 1, 2, Author
Affiliations:
1Behavioral Neurology Research Unit, Tampere University Hospital, Finland, ou_persistent22              
2Faculty of Medicine and Life Sciences, University of Tampere, Finland, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
4Department of Psychology, Saint Mary’s College of California, Moraga, CA, ou_persistent22              

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Free keywords: Attention; Cognitive control; Executive function; Emotion; EEG; ERP; Orbitofrontal cortex; Human studies
 Abstract: Patients with lesion to the orbitofrontal cortex (OFC) experience challenges in emotional control and emotion-guided behaviors. The OFC is known to participate in executive functions and attentional control of emotion and our previous research suggests OFC lesion alters the balance between voluntary and involuntary attention and cognitive control within the context of emotion. To better understand how OFC lesion affects the dynamics and interaction of these functions, we studied EEG and performance of 12 patients with lesion to the OFC and 11 control subjects with intact OFC in a Go/NoGo visual reaction time (RT) task with neutral targets and intervening threat-related emotional distractors (Executive RT Test). Event-related potentials (ERPs), specifically N2P3 peak-to-peak amplitude and the following late positive potential (LPP), were used to measure allocation of attention and cognitive control to emotional distractors. Task performance and Behavior Rating Inventory of Executive Functions—Adult version (BRIEF-A) scores were used to assess executive functions. As expected, the Control group showed increased N2P3 amplitude in the context of threat-related distractors, particularly over the right hemisphere, while LPP was not modulated by these distractors. In contrast, patients with OFC lesion showed no such impact of threat-related distractors on N2P3 amplitude but exhibited increased and prolonged left-lateralized impact of threat on LPP in the Go-condition. In NoGo-condition, the N2P3 amplitude was increased in both groups due to threat, but the impact was seen earlier, i.e., at the N2 peak in the OFC group and later at the P3 peak in Controls. The OFC group committed more errors in the Executive RT Test and reported more problems in BRIEF-A, thus both objective and subjective evidence for challenges in executive functions was obtained in patients with orbitofrontal lesion. Furthermore, the time-course of attention allocation and cognitive control towards task-irrelevant emotional stimuli was altered as evidenced by ERPs. We conclude that orbitofrontal lesion is associated with altered neural dynamics underlying the interaction of involuntary attention to emotion and cognitive control. These alterations in brain dynamics may underlie some of the challenges patients encounter in everyday life when emotional events interact with cognitive demands.

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Language(s): eng - English
 Dates: 2018-04-232018-10-042018-11-01
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnhum.2018.00437
PMID: 30443211
PMC: PMC6221981
Other: eCollection 2018
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Funding organization : Academy of Finland
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Funding program : Competitive State Research Financing of the Expert Responsibility area
Funding organization : Tampere University Hospital
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Funding organization : The Finnish Medical Foundation (Suomen Lääketieteen Säätiö)
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Funding organization : Orion Research Foundation (Orionin Tutkimussäätiö)
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Funding organization : The Paulo Foundation (Paulon Säätiö)

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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 12 Sequence Number: 437 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5161