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  Fast track to the neocortex: A memory engram in the posterior parietal cortex

Brodt, S., Gais, S., Beck, J., Erb, M., Scheffler, K., & Schönauer, M. (2018). Fast track to the neocortex: A memory engram in the posterior parietal cortex. Science, 362(4618), 1045-1048. doi:10.1126/science.aau2528.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-97A3-B Version Permalink: http://hdl.handle.net/21.11116/0000-0002-97A4-A
Genre: Journal Article

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Brodt, S1, 2, Author              
Gais, S, Author
Beck, J, Author
Erb, M1, 2, Author              
Scheffler, K1, 2, Author              
Schönauer, M1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Models of systems memory consolidation postulate a fast-learning hippocampal store and a slowly developing, stable neocortical store. Accordingly, early neocortical contributions to memory are deemed to reflect a hippocampus-driven online reinstatement of encoding activity. In contrast, we found that learning rapidly engenders an enduring memory engram in the human posterior parietal cortex. We assessed microstructural plasticity via diffusion-weighted magnetic resonance imaging as well as functional brain activity in an object-location learning task. We detected neocortical plasticity as early as 1 hour after learning and found that it was learning specific, enabled correct recall, and overlapped with memory-related functional activity. These microstructural changes persisted over 12 hours. Our results suggest that new traces can be rapidly encoded into the parietal cortex, challenging views of a slow-learning neocortex.

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 Dates: 2018-11
 Publication Status: Published in print
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 Identifiers: DOI: 10.1126/science.aau2528
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Title: Science
  Other : Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 362 (4618) Sequence Number: - Start / End Page: 1045 - 1048 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1