English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The BOLD sensitivity of rapid steady-state sequences

Scheffler, K., Heule, R., Baez-Yanez, M., Kardatzki, B., & Lohmann, G. (2019). The BOLD sensitivity of rapid steady-state sequences. Magnetic Resonance in Medicine, 81(4), 2526-2535. doi:10.1002/mrm.27585.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0002-97A7-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-FD73-0
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Scheffler, K1, 2, Author              
Heule, R1, 2, Author              
Baez-Yanez, MG1, 2, Author              
Kardatzki, B, Author              
Lohmann, G1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

Content

show
hide
Free keywords: -
 Abstract: Purpose Relaxation and dephasing of water protons embedded in a vascular network is driven by local magnetic field inhomogeneities around deoxygenated blood vessels. These effects strongly depend on the relation between mean diffusion length and diameter of blood vessels, as well as on the chosen imaging sequence. In this work, the BOLD sensitivity of steady‐state sequences as a function of vessel size, field strength, and sequence parameters are analyzed. Methods Steady‐state magnetization within a network of artificial cylinders is simulated with Monte Carlo methods for different coherence pathways. In addition, measurements on microspheres were performed to confirm theoretical results. Results Simulations and phantom results demonstrate a vessel size‐dependent signal attenuation effect of all coherence pathways. Both the FID and ECHO pathways show a signal profile similar to spin echo sequences where in the static dephasing regime the effect of larger vessels is suppressed. Conclusion The BOLD effect measured in steady‐state sequences is most sensitive to microvessels and might therefore be closer to the underlying neuronal event compared to gradient echo sequences.

Details

show
hide
Language(s):
 Dates: 2018-112019-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/mrm.27585
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Magnetic Resonance in Medicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 81 (4) Sequence Number: - Start / End Page: 2526 - 2535 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149