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  Exenatide Increases Hypothalamic Connectivity in Obese Men: First Evidence of Central appetite modulating Effects in fMRI Analyzed With Eigenvector Centrality Mapping

Schloegl, H., Villringer, A., Kabisch, S., Horstmann, A., Lepsien, J., Mueller, K., et al. (2010). Exenatide Increases Hypothalamic Connectivity in Obese Men: First Evidence of Central appetite modulating Effects in fMRI Analyzed With Eigenvector Centrality Mapping. Poster presented at 28th Annual Scientific Meeting of the Obesity Society (OBESITY 2010), San Diego, CA, USA.

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Schloegl, H, Author
Villringer, A, Author
Kabisch, S, Author
Horstmann, A, Author
Lepsien, J, Author
Mueller, K, Author
Kratzsch, J, Author
Busse, FP, Author
Pleger, B, Author
Stumvoll, M, Author
Lohmann, G1, Author              
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1External Organizations, ou_persistent22              

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 Abstract: Exenatide is a glucagon-like peptide-1 (GLP-1) analog, used in clinical practice for treatment of type-2-diabetes. It increases energy intake and reduces body weight in long-term treatment in humans, but the underlying physiological mechanisms are still unclear. To investigate its central nervous effects we performed functional magnetic resonance imaging (fMRI) in 20 male obese (body mass index 28.4 - 42.8 kg/m², mean 34.6 kg/m²; age 20 - 47 years, mean 28 years) while intravenously administrating exenatide. Infusion rate was 0.12 pmol/kg/min., total duration of infusion was 2.5 hours, the study design was cross-over, placebo controlled, double-blind and randomized. Inside the scanner subjects rated pictures of food regarding their tastiness. We used a recently published parameter-free method called ‘eigenvector centrality mapping’ (ECM) for assessing functional con- nectivity in each voxel (Lohmann et al. 2010). ECM attributes a centrality value to each voxel reflecting its degree of connectedness. Results showed a statistically significant global maximum for higher centrality (which suggests a higher connectivity) in hypothalamus in the exenatide condition compared to placebo. The hypothalamus is a key region for the control of energy homeostasis, where from animal data it is known that GLP-1 receptors are present and involved in regulation of energy uptake. Our results demonstrate that peripherally administered exenatide mediates centrality in food-related networks. This shows for the first time a modulation of central networks regulating energy homeostasis after exenatide infusion and suggests a central nervous mechanism for the reduction of energy intake under influence of exenatide.

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 Dates: 2010-11
 Publication Status: Published in print
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 Identifiers: DOI: 10.1038/oby.2010.158
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Title: 28th Annual Scientific Meeting of the Obesity Society (OBESITY 2010)
Place of Event: San Diego, CA, USA
Start-/End Date: 2010-10-09 - 2010-10-11

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Title: Obesity
  Other : Obesity : The Official Publication of NAASO, the Obesity Society
  Abbreviation : Obesity (Silver Spring)
Source Genre: Journal
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Publ. Info: Hoboken, NJ : Wiley
Pages: - Volume / Issue: 18 (Supplement 2) Sequence Number: 131-P Start / End Page: S77 Identifier: CoNE: https://pure.mpg.de/cone/journals/resource/1071-7323