English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes

Dang, T.-T.-T., Franke, J., Carqueijeiro, I. S. T., Langley, C., Courdavault, V., & O'Connor, S. E. (2018). Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes. Nature Chemical Biology, 14(8), 760-763. doi:10.1038/s41589-018-0078-4.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-0002-BB26-1 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-3C3D-1
Genre: Journal Article

Files

show Files
hide Files
:
SOC068.pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
SOC068.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Chemical Ecology, MJCO; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
SOC068s1.pdf (Supplementary material), 6MB
 
File Permalink:
-
Name:
SOC068s1.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Chemical Ecology, MJCO; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Dang, Thu-Thuy T.1, Author
Franke, Jakob1, Author
Carqueijeiro, Ines Soares Teto1, Author
Langley, Chloe1, Author
Courdavault, Vincent1, Author
O'Connor, Sarah E.1, Author           
Affiliations:
1external, ou_persistent22              

Content

show
hide
Free keywords: INDOLE ALKALOID BIOSYNTHESIS; GEISSOSCHIZINE METHYL-ETHER; CATHARANTHUS-ROSEUS; NATURAL-PRODUCTS; SERPENTINE; AJMALINE; VECTORBiochemistry & Molecular Biology;
 Abstract: Cyclization reactions that create complex polycyclic scaffolds are hallmarks of alkaloid biosynthetic pathways. We present the discovery of three homologous cytochrome P450s from three monoterpene indole alkaloid-producing plants (Rauwolfia serpentina, Gelsemium sempervirens and Catharanthus roseus) that provide entry into two distinct alkaloid classes, the sarpagans and the beta-carbolines. Our results highlight how a common enzymatic mechanism, guided by related but structurally distinct substrates, leads to either cyclization or aromatization.

Details

show
hide
Language(s): eng - English
 Dates: 2018
 Publication Status: Issued
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: SOC068
DOI: 10.1038/s41589-018-0078-4
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature Chemical Biology
  Other : Nat. Chem. Biol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Nature Pub. Group
Pages: - Volume / Issue: 14 (8) Sequence Number: - Start / End Page: 760 - 763 Identifier: ISSN: 1552-4450
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000021290_1