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  Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis

Jakubczyk, D., Caputi, L., Stevenson, C. E. M., Lawson, D. M., & O'Connor, S. E. (2016). Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis. Chemical Communications, 52(99), 14306-14309. doi:10.1039/c6cc08438a.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-B89A-1 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-C768-2
Genre: Journal Article

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SOC059.pdf (Publisher version), 2MB
 
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SOC059s1.pdf (Supplementary material), 769KB
 
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http://dx.doi.org/10.1039/c6cc08438a (Publisher version)
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 Creators:
Jakubczyk, Dorota1, Author
Caputi, Lorenzo2, Author           
Stevenson, Clare E. M.1, Author
Lawson, David M.1, Author
O'Connor, Sarah E.1, Author           
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1external, ou_persistent22              
2External Organizations, ou_persistent22              

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Free keywords: ERGOT ALKALOID BIOSYNTHESIS; DIOXYGENASE; ENZYME; FUNGIChemistry;
 Abstract: Aj_EasH is a non-heme iron-and alpha-keto-glutarate-dependent oxidase that is responsible for an unusual cyclopropyl ring formation in the biosynthesis of the fungal ergot alkaloid cycloclavine. The three dimensional structure of Aj_EasH (2.2 A resolutn) reported here provides insight into the mechanism of this unusual and complex reaction.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: SOC059
DOI: 10.1039/c6cc08438a
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Title: Chemical Communications
  Other : Chem. Commun.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 52 (99) Sequence Number: - Start / End Page: 14306 - 14309 Identifier: ISSN: 1359-7345
CoNE: https://pure.mpg.de/cone/journals/resource/954928495413