English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Structural determinants of reductive terpene cyclization in iridoid biosynthesis

Kries, H., Caputi, L., Stevenson, C. E. M., Kamileen, M. O., Sherden, N. H., Geu-Flores, F., et al. (2016). Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Nature Chemical Biology, 12(1), 6-8. doi:10.1038/nchembio.1955.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
SOC058.pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
SOC058.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Chemical Ecology, MJCO; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
SOC058s1.pdf (Supplementary material), 7MB
 
File Permalink:
-
Name:
SOC058s1.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Chemical Ecology, MJCO; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
OA

Creators

show
hide
 Creators:
Kries, Hajo1, Author
Caputi, Lorenzo1, Author              
Stevenson, Clare E. M.1, Author
Kamileen, Mohammed O.1, Author
Sherden, Nathaniel H.1, Author
Geu-Flores, Fernando1, Author
Lawson, David M.1, Author
O'Connor, Sarah E.1, Author              
Affiliations:
1external, ou_persistent22              

Content

show
hide
Free keywords: PROGESTERONE 5-BETA-REDUCTASE; DIGITALIS-LANATA; STRUCTURE VALIDATION; CARDENOLIDES; REFINEMENT; CHEMISTRY; BIOLOGY; FAMILYBiochemistry & Molecular Biology;
 Abstract: The carbon skeleton of ecologically and pharmacologically important iridoid monoterpenes is formed in a reductive cyclization reaction unrelated to canonical terpene cyclization. Here we report the crystal structure of the recently discovered iridoid cyclase (from Catharanthus roseus) bound to a mechanism-inspired inhibitor that illuminates substrate binding and catalytic function of the enzyme. Key features that distinguish iridoid synthase from its close homolog progesterone 5 beta-reductase are highlighted.

Details

show
hide
Language(s): eng - English
 Dates: 2016
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: SOC058
DOI: 10.1038/nchembio.1955
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature Chemical Biology
  Other : Nat. Chem. Biol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Nature Pub. Group
Pages: - Volume / Issue: 12 (1) Sequence Number: - Start / End Page: 6 - 8 Identifier: ISSN: 1552-4450
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000021290_1