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  Engineering of secondary metabolism

O'Connor, S. E. (2015). Engineering of secondary metabolism. In Annual Review of Genetics (pp. 71-94). Palo Alto, Calif.: Annual Reviews, Inc.

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SOC049.pdf (Publisher version), 393KB
 
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O'Connor, Sarah E.1, Author              
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Free keywords: NATURAL-PRODUCT BIOSYNTHESIS; DE-NOVO PRODUCTION; ESCHERICHIA-COLI; SACCHAROMYCES-CEREVISIAE; SYNTHETIC BIOLOGY; POLYKETIDE SYNTHASE; COMBINATORIAL BIOSYNTHESIS; GENE CLUSTERS; E. COLI; STREPTOMYCES-COELICOLORGenetics & Heredity; natural product; secondary metabolite; synthetic biology; combinatorial biosynthesis; compartmentalization;
 Abstract: Secondary (specialized) metabolites, produced by bacteria, fungi, plants, and other organisms, exhibit enormous structural variation, and consequently display a wide range of biological activities. Secondary metabolism improves and modulates the phenotype of the host producer. Furthermore, these biological activities have resulted in the use of secondary metabolites in a variety of industrial and pharmaceutical applications. Metabolic engineering presents a powerful strategy to improve access to these valuable molecules. A critical overview of engineering approaches in secondary metabolism is presented, both in heterologous and native hosts. The recognition of the increasing role of compartmentalization in metabolic engineering is highlighted. Engineering approaches to modify the structure of key secondary metabolite classes are also critically evaluated.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Published in print
 Pages: 24
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: SOC049
DOI: 10.1146/annurev-genet-120213-092053
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Title: Annual Review of Genetics
  Other : Annu. Rev. Genet.
Source Genre: Journal
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Publ. Info: Palo Alto, Calif. : Annual Reviews, Inc.
Pages: - Volume / Issue: 49 Sequence Number: - Start / End Page: 71 - 94 Identifier: ISSN: 0066-4197
CoNE: https://pure.mpg.de/cone/journals/resource/954925458042