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  Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids

Kellner, F., Geu-Flores, F., Sherden, N. H., Brown, S., Foureau, E., Courdavault, V., et al. (2015). Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids. Chemical Communications, 51(36), 7626-7628. doi:10.1039/c5cc01309g.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-B58C-4 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-3C6E-A
Genre: Journal Article

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SOC048.pdf (Publisher version), 2MB
 
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SOC048s1.pdf (Supplementary material), 6MB
 
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 Creators:
Kellner, Franziska1, Author
Geu-Flores, Fernando1, Author
Sherden, Nathaniel H.1, Author
Brown, Stephanie1, Author
Foureau, Emilien1, Author
Courdavault, Vincent1, Author
O'Connor, Sarah E.1, Author           
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1external, ou_persistent22              

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Free keywords: CATHARANTHUS-ROSEUS; MOLECULAR-CLONING; TABERSONINE; VINCAMINE;VINCADIFFORMINE; CHEMISTRYChemistry;
 Abstract: Here we report the discovery of a cytochrome P450 that is required for the biosynthesis of vindoline, a plant-derived natural product used for semi-synthesis of several anti-cancer drugs. This enzyme catalyzes the formation of an epoxide that can undergo rearrangement to yield the vincamine-eburnamine backbone, thereby providing evidence for the long-standing hypothesis that the aspidosperma- and eburnamine-type alkaloids are biosynthetically related.

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Language(s): eng - English
 Dates: 2015
 Publication Status: Issued
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: SOC048
DOI: 10.1039/c5cc01309g
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Title: Chemical Communications
  Other : Chem. Commun.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 51 (36) Sequence Number: - Start / End Page: 7626 - 7628 Identifier: ISSN: 1359-7345
CoNE: https://pure.mpg.de/cone/journals/resource/954928495413