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  Metabolic reprogramming of periwinkle plant culture

Runguphan, W., & O'Connor, S. E. (2009). Metabolic reprogramming of periwinkle plant culture. Nature Chemical Biology, 5(3), 151-153. doi:10.1038/nchembio.141.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-A9AA-0 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-3D8D-5
Genre: Journal Article

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SOC020s1.pdf (Supplementary material), 2MB
 
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SOC020.pdf (Publisher version), 312KB
 
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749225/ (Postprint)
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 Creators:
Runguphan, Weerawat1, Author
O'Connor, Sarah E.1, Author           
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1external, ou_persistent22              

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Free keywords: ALKALOID BIOSYNTHESIS; BENZYLISOQUINOLINE ALKALOIDS; STRICTOSIDINE SYNTHASE; CATHARANTHUS-ROSEUS; PATHWAY; ENZYMEBiochemistry & Molecular Biology;
 Abstract: We transformed an alkaloid biosynthetic gene with reengineered substrate specificity into Catharanthus roseus. The resulting transgenic plant cell culture produced a variety of unnatural alkaloid compounds when cocultured with simple, achiral, commercially available precursors that the reengineered enzyme was designed to accept. This work demonstrates the power of genetic engineering to retailor the structures of complex alkaloid natural products in plant culture.

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Language(s): eng - English
 Dates: 2009
 Publication Status: Issued
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: SOC020
DOI: 10.1038/nchembio.141
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Title: Nature Chemical Biology
  Other : Nat. Chem. Biol.
Source Genre: Journal
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Publ. Info: New York, NY : Nature Pub. Group
Pages: - Volume / Issue: 5 (3) Sequence Number: - Start / End Page: 151 - 153 Identifier: ISSN: 1552-4450
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000021290_1