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Free keywords:
COMBINATORIAL BIOSYNTHESIS; POLYKETIDE BIOSYNTHESIS; ANTITUMOR DRUG;
MITHRAMYCIN; EVOLUTION; PRODUCTS; BONEBiochemistry & Molecular Biology;
Abstract:
In this issue of Chemistry & Biology, Mendez and colleagues describe the sequence and organization of the chromomycin gene cluster [20]. Unexpectedly, the arrangement is starkly different from the mithramycin biosynthetic cluster, despite similarity in the individual genes and the near identical structures of the two antibiotic aureolic acids.