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  Nuclear singlet multimers (NUSIMERs) with long-lived singlet states.

Saul, P., Mamone, S., & Glöggler, S. (2019). Nuclear singlet multimers (NUSIMERs) with long-lived singlet states. Chemical Science, 10, 413-417. doi:10.1039/C8SC02831A.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-A174-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-B7E7-B
Genre: Journal Article

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Saul, P., Author
Mamone, S.1, Author              
Glöggler, S.1, Author              
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1Research Group of NMR Signal Enhancement, MPI for Biophysical Chemistry, Max Planck Society, ou_2396691              

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 Abstract: Magnetic resonance (NMR) is a powerful tool in chemical analysis, structure determination and in medical diagnostics. Developing novel biological sensors for this field holds promise to better investigate protein structures or target diseases more efficiently. Herein, we explore nuclear spin singlet states in dendritic macromolecules as a platform molecule to develop stimuli responsive probes. We have developed a nuclear singlet multimer (NUSIMER) based on a generation 5 poly(amidoamine) dendrimer (PAMAM) which contains on average about 90 accessible nuclear spin singlet states with lifetimes up to 10-fold longer than the T1 relaxation times (up to 10 seconds Tsvs. T1 < 0.5 seconds) in a single molecule. We demonstrate little influence on the singlet lifetime in phosphate buffer (H2O) and a high viscosity gel environment in the presence of paramagnetic oxygen. Additionally, we demonstrate an increase in singlet lifetime upon the release of a protective chemical moiety from the NUSIMER following a stimulus, whereby no change in longitudinal relaxation time is observed. The robustness and change in singlet lifetime of the NUSIMER holds promise for the development of a novel type of biosensors.

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Language(s): eng - English
 Dates: 2018-10-252019-01
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1039/C8SC02831A
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Title: Chemical Science
Source Genre: Journal
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Pages: - Volume / Issue: 10 Sequence Number: - Start / End Page: 413 - 417 Identifier: -