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  Dorsolateral and medial prefrontal cortex mediate the influence of incidental priming on economic decision making in obesity

Morys, F., Bode, S., & Horstmann, A. (2018). Dorsolateral and medial prefrontal cortex mediate the influence of incidental priming on economic decision making in obesity. Scientific Reports, 8: 17595. doi:10.1038/s41598-018-35834-1.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0002-A35B-0 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0003-96AC-2
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 Urheber:
Morys, Filip1, 2, Autor           
Bode, Stefan3, 4, Autor
Horstmann, Annette1, 2, 5, Autor           
Affiliations:
1Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3Melbourne School of Psychological Sciences, University of Melbourne, Australia, ou_persistent22              
4Department of Psychology, University of Cologne, Germany, ou_persistent22              
5Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              

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Schlagwörter: Cognitive control; Decision; Obesity; Reward
 Zusammenfassung: Obese individuals discount future rewards to a higher degree than lean individuals, which is generally considered disadvantageous. Moreover, their decisions are altered more easily by decision-irrelevant cues. Here, we investigated neural correlates of this phenomenon using functional MRI. We tested 30 lean and 26 obese human subjects on a primed delay discounting paradigm using gustatory and visual cues of positive, neutral and negative valence to bias their intertemporal preferences. We hypothesised that activation differences in reward-related and behavioural control areas, and changes in connectivity between these areas, would reflect the effect of these cues. Here, obese subjects were more susceptible to priming with negative gustatory cues towards delayed choices as opposed to lean subjects. This was related to lower activity in the left dorsolateral prefrontal cortex during priming. Modulation of functional connectivity between the dlPFC and the ventromedial PFC by the behavioural priming effect correlated negatively with BMI. This might indicate that default goals of obese individuals were different from those of lean participants, as the dlPFC has been suggested to be involved in internal goal pursuit. The present results further our understanding of the role of the PFC in decision-making and might inform future weight-management approaches based on non-invasive brain stimulation.

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Sprache(n): eng - English
 Datum: 2018-08-092018-11-062018-12-04
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/s41598-018-35834-1
PMID: 30514862
PMC: PMC6279740
 Art des Abschluß: -

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Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : German Research Foundation (DFG)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Leipzig University
Projektname : -
Grant ID : 01E01001
Förderprogramm : -
Förderorganisation : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)
Projektname : Obesity Mechanisms / SFB 1052
Grant ID : -
Förderprogramm : -
Förderorganisation : German Research Foundation (DFG)
Projektname : -
Grant ID : ARC DECRA DE140100350
Förderprogramm : Australian Research Council Discovery Early Career Researcher Award
Förderorganisation : Australian Research Council

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Titel: Scientific Reports
  Kurztitel : Sci. Rep.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: London, UK : Nature Publishing Group
Seiten: - Band / Heft: 8 Artikelnummer: 17595 Start- / Endseite: - Identifikator: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322