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  MR Spectroscopy without Water Suppression for the Determination of Proton Exchange Rates in the Human Brain

MacMillan, E., Chong, D., Dreher, W., Henning, A., Boesch, C., & Kreis, R. (2010). MR Spectroscopy without Water Suppression for the Determination of Proton Exchange Rates in the Human Brain. In ISMRM-ESMRMB Joint Annual Meeting 2010.

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 Creators:
MacMillan, EL, Author
Chong, DG, Author
Dreher, W, Author
Henning, A1, Author              
Boesch, C, Author
Kreis, R, Author
Affiliations:
1University and ETH Zürich, ou_persistent22              

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 Abstract: MRS without water suppression can detect exchangeable proton resonances, particularly downfield of water. Employing a two-acquisition scheme with alternating up- or down-field metabolite inversion prior to PRESS, both the metabolite and water spectra were obtained from the human brain in-vivo. The experiment was performed with and without a water inversion prepulse with varying inversion times (TI). The magnetization transfer curves were fit with a Bloch-McConnell two-site exchange model to determine exchange rates, with initial estimates yeilding lifetimes (1/Km¨w) ranging from 90ms to >2s, which offer information about pH and chemical microenvironments, and may aid in the understanding of CEST

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 Dates: 2010-05
 Publication Status: Published in print
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Title: ISMRM-ESMRMB Joint Annual Meeting 2010
Place of Event: Stockholm, Sweden
Start-/End Date: 2010-05-01 - 2010-05-07

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Title: ISMRM-ESMRMB Joint Annual Meeting 2010
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 316 Start / End Page: - Identifier: -