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  Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy

Belin, S., Ornaghi, F., Shackleford, G. G., Wang, J., Scapin, C., Lopez-Anido, C., et al. (2019). Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy. Human Molecular Genetics, 28(8), 1260-1273. doi:10.1093/hmg/ddy420.

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 Creators:
Belin, Sophie, Author
Ornaghi, Francesca, Author
Shackleford, Ghjuvan Ghjacumu, Author
Wang, Jie, Author
Scapin, Cristina, Author
Lopez-Anido, Camila, Author
Silvestri, Nicholas, Author
Robertson, Neil, Author
Williamson, Courtney, Author
Ishii, Akihiro, Author
Taveggia, Carla, Author
Svaren, John, Author
Bansal, Rashmi, Author
Schwab, Markus H.1, Author           
Nave, Klaus1, Author           
Fratta, Pietro, Author
D'Antonio, Maurizio, Author
Poitelon, Yannick, Author
Feltri, M. Laura, Author
Wrabetz, Lawrence, Author
Affiliations:
1Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society, ou_2173664              

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 Abstract: Myelin sheath thickness is precisely regulated and essential for rapid propagation of action potentials along myelinated axons. In the peripheral nervous system, extrinsic signals from the axonal protein neuregulin 1 (NRG1) type III regulate Schwann cell fate and myelination. Here we ask if modulating NRG1 type III levels in neurons would restore myelination in a model of congenital hypomyelinating neuropathy (CHN). Using a mouse model of CHN, we improved the myelination defects by early overexpression of NRG1 type III. Surprisingly, the improvement was independent from the upregulation of Egr2 or essential myelin genes. Rather, we observed the activation of MAPK/ERK and other myelin genes such as peripheral myelin protein 2 and oligodendrocyte myelin glycoprotein. We also confirmed that the permanent activation of MAPK/ERK in Schwann cells has detrimental effects on myelination. Our findings demonstrate that the modulation of axon-to-glial NRG1 type III signaling has beneficial effects and improves myelination defects during development in a model of CHN.

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Language(s): eng - English
 Dates: 2018-12-102019-01-212019-04-15
 Publication Status: Issued
 Pages: -
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 Rev. Type: Peer
 Identifiers: DOI: 10.1093/hmg/ddy420
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Title: Human Molecular Genetics
Source Genre: Journal
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Publ. Info: Oxford, England : IRL Press
Pages: - Volume / Issue: 28 (8) Sequence Number: - Start / End Page: 1260 - 1273 Identifier: ISSN: 0964-6906
CoNE: https://pure.mpg.de/cone/journals/resource/954925581153