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  An unusual defective genotype derived from herpes simplex virus strain ANG

Schröder, C., Stegmann, B., Lauppe, H.-F., & Kaerner, H. C. (1975). An unusual defective genotype derived from herpes simplex virus strain ANG. Intervirology, 6(4-5), 270-284. doi:10.1159/000149481.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-B06B-F Version Permalink: https://hdl.handle.net/21.11116/0000-0002-B15C-F
Genre: Journal Article

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Intervirology_6_1975_270.pdf (Any fulltext), 2MB
 
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Schröder, C.H., Author
Stegmann , B., Author
Lauppe, Hans-Frieder1, Author           
Kaerner, Hans Christian1, Author           
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1Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              

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 Abstract: A defective genotype of herpes simplex virus strain Angelotti (HSV ANG) accumulates in the course of controlled serial high MOI virus passages representing 50–60% of the total number of mature virions in the seventh of these passages. Defective HSV ANG significantly differs from other defective HSV genotypes described so far: the DNA of the defective particles has the same buoyant density as nondefective DNA. In contrast to non-defective HSV ANG DNA, it is not attacked by the restriction endonucleases Eco R I, Hpa I and Hind III. Defective virions strongly suppress the formation of progeny virus. They do not interfere, however, with the synthesis of HSV-specified thymidine (TdR) kinase.

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Language(s): eng - English
 Dates: 1975-12-292008-07-241975
 Publication Status: Issued
 Pages: 18
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1159/000149481
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Title: Intervirology
Source Genre: Journal
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Publ. Info: Basel ; Freiburg, Br. ; Paris ; London ; New York,NY ; Bangalore ; Bangkok ; Shanghai ; Singapore ; Tokyo ; Sydney : Virology Section, International Association of Microbiological Societies
Pages: - Volume / Issue: 6 (4-5) Sequence Number: - Start / End Page: 270 - 284 Identifier: ISSN: 0300-5526