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  Citalopram improves obsessive-compulsive crossword puzzling in frontotemporal dementia

Meyer, S., Mueller, K., Gruenewald, C., Grundl, K., Marschhauser, A., Tiepolt, S., et al. (2019). Citalopram improves obsessive-compulsive crossword puzzling in frontotemporal dementia. Case Reports in Neurology, 11(1), 94-105. doi:10.1159/000495561.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-4057-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-ECE0-6
Genre: Journal Article

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Meyer_Mueller_Gruenewald_2019.pdf (Publisher version), 610KB
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 Creators:
Meyer, Sebastian 1, Author
Mueller, Karsten2, Author              
Gruenewald, Christin 3, Author
Grundl, Kristin 3, Author
Marschhauser, Anke 3, Author
Tiepolt, Solveig 4, Author
Barthel, Henryk 4, Author
Sabri, Osama 4, Author
Schroeter, Matthias L.1, 3, 5, 6, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
2Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
5Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
6Consortium for Frontotemporal Lobar Degeneration, Ulm, Germany, ou_persistent22              

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Free keywords: Behavioral variant frontotemporal dementia; Citalopram; Obsessive-compulsive behavior; Selective serotonin reuptake inhibitors; Serotonin
 Abstract: Behavioral variant frontotemporal dementia (bvFTD) is characterized by severe changes in personality/behavior. Recent studies have provided evidence that a decrease in serotonin receptors and neuronal loss in the raphe nuclei play a role in bvFTD’s pathology. Serotonergic antidepressants have been reported to diminish behavioral disturbances in bvFTD, in particular repetitive behaviors, disinhibition, apathy, sexually inappropriate behaviors, and hyperorality. Here we present the case of a 80-year-old Caucasian male patient with clinically and biomarker supported bvFTD (“probable” bvFTD; disease-specific alterations in [18F]fluorodesoxyglucose positron emission tomography and magnetic resonance imaging). The patient exhibited behavioral disinhibition, apathy, a loss of empathy, perseverative behavior during testing, hyperorality, changes in diet, and executive deficits in neuropsychological testing. Remarkably, he failed in solving crosswords by systematically filling in the blanks by letters in alphabetical order (A, B, C, D etc.) indicating obsessive-compulsive behavior. One year later the patient visited the clinic again for a follow up investigation. He had taken 20 mg of citalopram per day for one consecutive year. Remarkably, he had regained the ability to fill in cross-word puzzles correctly, although the neuropsychiatric inventory showed overall only small improvement in behavioral impairment. A regiment of 20 mg citalopram per day over the course of one year led to a specific improvement in one of bvFTD’s core symptoms – obsessive-compulsive behavior – most pronounced in solving cross-word puzzles. This case contributes to the understanding of the neuropharmacological correlates of bvFTD, and supports treatment of bvFTD’s behavioral symptoms with selective serotonin reuptake inhibitors.

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Language(s): eng - English
 Dates: 2018-10-042018-11-152019-03-192019-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1159/000495561
PMID: 31011326
PMC: PMC6465705
Other: eCollection 2019
 Degree: -

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Project name : -
Grant ID : O1GI1007A
Funding program : German Consortium for Frontotemporal Lobar Degeneration
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : PDF-IRG-1307
Funding program : -
Funding organization : Parkinson’s Disease Foundation
Project name : -
Grant ID : MJFF-13362
Funding program : -
Funding organization : Michael J. Fox Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : LIFE – Leipzig Research Center for Civilization Diseases at the University of Leipzig
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Grant ID : -
Funding program : -
Funding organization : European Union (EU)
Project name : -
Grant ID : -
Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Free State of Saxony
Project name : -
Grant ID : SCHR 774/5-1
Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: Case Reports in Neurology
Source Genre: Journal
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Publ. Info: Basel : Karger
Pages: - Volume / Issue: 11 (1) Sequence Number: - Start / End Page: 94 - 105 Identifier: ISSN: 1662-680X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-680X