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  Two antiproliferative seco-4,5-abietane diterpenoids from roots of Salvia ceratophylla L.

Mirzaei, H. H., Firuzi, O., Chandran, J. N., Schneider, B., & Jassbi, A. R. (2019). Two antiproliferative seco-4,5-abietane diterpenoids from roots of Salvia ceratophylla L. Phytochemistry Letters, 29, 129-133. doi:10.1016/j.phytol.2018.11.017.

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NMR257.pdf (Publisher version), 909KB
 
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Mirzaei, Hossein Hadavand, Author
Firuzi, Omidreza, Author
Chandran, Jima N.1, Author              
Schneider, Bernd1, Author              
Jassbi, Amir Reza, Author
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1Research Group Biosynthesis / NMR, MPI for Chemical Ecology, Max Planck Society, ou_421898              

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 Abstract: Two previously undescribed rearranged abietanes, ceratol (1) and ceratodiol (2), and three known abietanediterpenoids, including 1-ketoaethiopinone (3), ferruginol (4) and 12-deoxysalvipisone (5), were isolated from roots of Salvia ceratophylla. The structures of the purified compounds (1–5) were characterized based on analyses of their spectroscopic data, including 1D and 2D NMR and high-resolution electrospray mass spectra. The analytical data were then compared with those reported in the literature. Cytotoxicity of the isolated compounds was examined against two human cancer cell lines, MOLT-4 (human lymphoblastic leukemia) and MCF-7 (human breast adenocarcinoma), using the MTT reduction assay. Whereas compound 2 showed cytotoxicity against both cancer cells, 1 showed weak toxicity against MOLT-4 cells and no toxicity against MCF-7 cells. Compound 3 and compound 5, both of which had an α, β-unsaturated carbonyl function, showed the highest cytotoxic activities among the tested compounds.

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 Dates: 2018-11-272018-122019
 Publication Status: Published in print
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 Identifiers: Other: NMR257
DOI: 10.1016/j.phytol.2018.11.017
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Title: Phytochemistry Letters
Source Genre: Journal
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Publ. Info: Amsterdam [u.a.] : Elsevier
Pages: - Volume / Issue: 29 Sequence Number: - Start / End Page: 129 - 133 Identifier: ISSN: 1874-3900
CoNE: https://pure.mpg.de/cone/journals/resource/1874-3900