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  Effective connectivity between ventral occipito-temporal and ventral inferior frontal cortex during lexico-semantic Processing: A dynamic causal modeling study

Perrone-Bertolotti, M., Kauffmann, L., Pichat, C., Vidal, J. R., & Baciu, M. (2017). Effective connectivity between ventral occipito-temporal and ventral inferior frontal cortex during lexico-semantic Processing: A dynamic causal modeling study. Frontiers in Human Neuroscience, 11: 325. doi:10.3389/fnhum.2017.00325.

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 Creators:
Perrone-Bertolotti, Marcela 1, Author
Kauffmann, Louise1, 2, Author              
Pichat, Cédric 1, Author
Vidal, Juan R. 1, Author
Baciu, Monica , Author
Affiliations:
1Department of Psychology, Université Grenoble Alpes, Grenoble, France, ou_persistent22              
2Max Planck Research Group Neural Mechanisms of Human Communication, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634556              

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Free keywords: dorsal inferior frontal cortex; dorsal stream; phonology; semantic; ventral inferior frontal cortex; ventral occipito-temporal cortex; ventral stream
 Abstract: It has been suggested that dorsal and ventral pathways support distinct aspects of language processing. Yet, the full extent of their involvement and their inter-regional connectivity in visual word recognition is still unknown. Studies suggest that they might reflect the dual-route model of reading, with the dorsal pathway more involved in grapho-phonological conversion during phonological tasks, and the ventral pathway performing lexico-semantic access during semantic tasks. Furthermore, this subdivision is also suggested at the level of the inferior frontal cortex, involving ventral and dorsal parts for lexico-semantic and phonological processing, respectively. In the present study, we assessed inter-regional brain connectivity and task-induced modulations of brain activity during a phoneme detection and semantic categorization tasks, using fMRI in healthy subject. We used a dynamic causal modeling approach to assess inter-regional connectivity and task demand modulation within the dorsal and ventral pathways, including the following network components: the ventral occipito-temporal cortex (vOTC; dorsal and ventral), the superior temporal gyrus (STG; dorsal), the dorsal inferior frontal gyrus (dIFG; dorsal), and the ventral IFG (vIFG; ventral). We report three distinct inter-regional interactions supporting orthographic information transfer from vOTC to other language regions (vOTC -> STG, vOTC -> vIFG and vOTC -> dIFG) regardless of task demands. Moreover, we found that (a) during semantic processing (direct ventral pathway) the vOTC -> vIFG connection strength specifically increased and (b) a lack of modulation of the vOTC -> dIFG connection strength by the task that could suggest a more general involvement of the dorsal pathway during visual word recognition. Results are discussed in terms of anatomo-functional connectivity of visual word recognition network.

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Language(s): eng - English
 Dates: 2016-10-112017-06-062017-06-22
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fnhum.2017.00325
PMC: PMC5480016
PMID: 28690506
Other: eCollection 2017
 Degree: -

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Project name : Infrastructure d’avenir en Biologie Santé
Grant ID : ANR-11-INBS-0006
Funding program : Investissement d’Avenir
Funding organization : Agence Nationale pour la Recherche (ANR)
Project name : -
Grant ID : -
Funding program : AGIR PEPS founding
Funding organization : Univeristé Grenoble Alpes

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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 11 Sequence Number: 325 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5161