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  Change, stability, and instability in the Pavlovian guidance of behaviour from adolescence to young adulthood

Moutoussis, M., Bullmore, E., Goodyer, I., Fonagy, P., Jones, P., Dolan, R., et al. (2018). Change, stability, and instability in the Pavlovian guidance of behaviour from adolescence to young adulthood. PLoS Computational Biology, 14(12), 1-26. doi:10.1371/journal.pcbi.1006679.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-B747-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-BD6D-0
Genre: Journal Article

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Moutoussis, M, Author
Bullmore, ET, Author
Goodyer, IM, Author
Fonagy, P, Author
Jones, PB, Author
Dolan, RJ, Author
Dayan, P1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department of Computational Neuroscience, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_3017468              

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 Abstract: Pavlovian influences are important in guiding decision-making across health and psychopathology. There is an increasing interest in using concise computational tasks to parametrise such influences in large populations, and especially to track their evolution during development and changes in mental health. However, the developmental course of Pavlovian influences is uncertain, a problem compounded by the unclear psychometric properties of the relevant measurements. We assessed Pavlovian influences in a longitudinal sample using a well characterised and widely used Go-NoGo task. We hypothesized that the strength of Pavlovian influences and other ‘psychomarkers’ guiding decision-making would behave like traits. As reliance on Pavlovian influence is not as profitable as precise instrumental decision-making in this Go-NoGo task, we expected this influence to decrease with higher IQ and age. Additionally, we hypothesized it would correlate with expressions of psychopathology. We found that Pavlovian effects had weak temporal stability, while model-fit was more stable. In terms of external validity, Pavlovian effects decreased with increasing IQ and experience within the task, in line with normative expectations. However, Pavlovian effects were poorly correlated with age or psychopathology. Thus, although this computational construct did correlate with important aspects of development, it does not meet conventional requirements for tracking individual development. We suggest measures that might improve psychometric properties of task-derived Pavlovian measures for future studies.

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 Dates: 2018-12
 Publication Status: Published online
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 Identifiers: DOI: 10.1371/journal.pcbi.1006679
eDoc: e1006679
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Title: PLoS Computational Biology
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 14 (12) Sequence Number: - Start / End Page: 1 - 26 Identifier: ISSN: 1553-734X
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000017180_1