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  Neural correlates of hypokinetic dysarthria and mechanisms of effective voice treatment in Parkinson disease

Baumann, A., Nebel, A., Granert, O., Giehl, K., Wolff, S., Schmidt, W., et al. (2018). Neural correlates of hypokinetic dysarthria and mechanisms of effective voice treatment in Parkinson disease. Neurorehabilitation and Neural Repair, 32(12), 1055-1066. doi:10.1177/1545968318812726.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-B9CF-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-934D-1
Genre: Journal Article

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 Creators:
Baumann, Alexander 1, Author
Nebel, Adelheid 1, Author
Granert, Oliver 1, Author
Giehl, Kathrin 2, Author
Wolff, Stephan 1, Author
Schmidt, Wiebke1, Author
Baasch, Christin1, Author
Schmidt, Gerhard 1, Author
Witt, Karsten 3, Author
Deuschl, Günther 1, Author
Hartwigsen, Gesa4, Author              
Zeuner, Kirsten E. 1, Author
van Eimeren, Thilo 2, 5, 6, Author
Affiliations:
1Christian Albrecht University Kiel, Germany, ou_persistent22              
2University Hospital Cologne, Germany, ou_persistent22              
3Carl von Ossietzky University of Oldenburg, Germany, ou_persistent22              
4Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
5Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
6German Center for Neurodegenerative Diseases, Bonn, Germany, ou_persistent22              

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Free keywords: Idiopathic Parkinson’s disease; Hypokinetic dysarthria; Speech therapy; Lee Silverman Voice Treatment; Functional magnetic resonance imaging
 Abstract: Background. Hypokinetic dysarthria is highly prevalent in idiopathic Parkinson disease (PD), and effectiveness of high-intensity voice treatment is well established. However, the neural correlates remain largely unknown. Objective. We aimed to specify cerebral pathophysiology of hypokinetic dysarthria and treatment-induced changes using functional magnetic resonance imaging (fMRI). Methods. We used fMRI to investigate healthy controls (HCs) and patients with idiopathic PD–associated dysarthria before and after treatment according to the Lee Silverman Voice Treatment LOUD (LSVT). During fMRI, participants covertly read sentences with normal (eg, conversation in a quiet room) or high (eg, shouting on a windy beach) intensity. In addition, we tested LSVT effects on intelligibility and different speech features (intensity, pitch, articulation). Results. LSVT effectively improved intelligibility, articulation, and pitch in patients. Covert high-intensity speech compared with covert normal-intensity speech led to increased activation of mainly secondary motor areas and bilateral superior and medial temporal regions. Prior to LSVT, patients showed less activity in several speech-associated areas compared with HCs. As a neural correlate of effective LSVT, increased right-sided superior temporal activity correlated with improved intelligibility. Conclusion. This is the first brain imaging study using a covert speech paradigm in PD, which revealed cortical hypoactivation as correlate of hypokinetic dysarthria. Furthermore, cortical correlates of effective LSVT treatment colocalized with the neuronal network, showing increased activation during high- versus normal-intensity speech generation.

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Language(s): eng - English
 Dates: 2018-11-162018-12-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1177/1545968318812726
PMID: 30444176
Other: Epub 2018
 Degree: -

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Project name : -
Grant ID : EI 892 3-1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: Neurorehabilitation and Neural Repair
Source Genre: Journal
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Publ. Info: Thousand Oaks, CA, USA : Sage
Pages: - Volume / Issue: 32 (12) Sequence Number: - Start / End Page: 1055 - 1066 Identifier: ISSN: 0888-4390
CoNE: https://pure.mpg.de/cone/journals/resource/0888-4390