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  Cross-species immune recognition between plasmodium vivax duffy binding protein antibodies and the plasmodium falciparum surface antigen VAR2CSA

Gnidehou, S., Mitran, C. J., Arango, E., Banman, S., Mena, A., Medawar, E., et al. (2019). Cross-species immune recognition between plasmodium vivax duffy binding protein antibodies and the plasmodium falciparum surface antigen VAR2CSA. The Journal of Infectious Diseases, 219(1), 110-120. doi:10.1093/infdis/jiy467.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-BB57-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9683-F
Genre: Journal Article

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 Creators:
Gnidehou, Sédami1, Author
Mitran, Catherine J.2, Author
Arango, Eliana3, Author
Banman, Shanna 2, Author
Mena, Angie 2, Author
Medawar, Evelyn2, Author              
Lima, Barbara A. S. 4, Author
Doritchamou, Justin 5, Author
Rajwani, Jahanara 2, Author
Jin, Albert 2, Author
Gavina, Kenneth 6, Author
Ntumngia, Francis 7, Author
Duffy, Patrick 5, Author
Narum, David 5, Author
Ndam , Nicaise Tuikue8, Author
Nielsen, Morten A.9, Author
Salanti, Ali 9, Author
Kano, Flora S. 4, Author
Carvalho, Luzia H.4, Author
Adams, John H. 7, Author
Maestre, Amanda 3, AuthorGood, Michael F.10, AuthorYanow, Stephanie K.2, 6, Author more..
Affiliations:
1Department of Biology, University of Alberta, Edmonton, AB, Canada , ou_persistent22              
2School of Public Health, University of Alberta, Edmonton, AB, Canada, ou_persistent22              
3Grupo Salud y Comunidad, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia , ou_persistent22              
4Fundação Oswaldo Cruz, Belo Horizonte, Brazil, ou_persistent22              
5National Institute of Allergy and Infectious Diseases, Rockville, MD, USA, ou_persistent22              
6Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada , ou_persistent22              
7University of South Florida, Tampa, FL, USA, ou_persistent22              
8Research Institute for Development, Paris, France, ou_persistent22              
9Department of Immunology and Microbiology, Center for Medical Parasitology, University of Copenhagen, Denmark , ou_persistent22              
10Institute for Glycomics, Griffith University, Gold Coast, Australia , ou_persistent22              

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Free keywords: Vivax; Falciparum; Pregnancy; PvDBP; VAR2CSA; Immunity; Placental malaria
 Abstract: Background In pregnancy, Plasmodium falciparum parasites express the surface antigen VAR2CSA, which mediates adherence of red blood cells to chondroitin sulfate A (CSA) in the placenta. VAR2CSA antibodies are generally acquired during infection in pregnancy and are associated with protection from placental malaria. We observed previously that men and children in Colombia also had antibodies to VAR2CSA, but the origin of these antibodies was unknown. Here, we tested whether infection with Plasmodium vivax is an alternative mechanism of acquisition of VAR2CSA antibodies. Methods We analyzed sera from nonpregnant Colombians and Brazilians exposed to P. vivax and monoclonal antibodies raised against P. vivax Duffy binding protein (PvDBP). Cross-reactivity to VAR2CSA was characterized by enzyme-linked immunosorbent assay, immunofluorescence assay, and flow cytometry, and antibodies were tested for inhibition of parasite binding to CSA. Results Over 50% of individuals had antibodies that recognized VAR2CSA. Affinity-purified PvDBP human antibodies and a PvDBP monoclonal antibody recognized VAR2CSA, showing that PvDBP can give rise to cross-reactive antibodies. Importantly, the monoclonal antibody inhibited parasite binding to CSA, which is the primary in vitro correlate of protection from placental malaria. Conclusions These data suggest that PvDBP induces antibodies that functionally recognize VAR2CSA, revealing a novel mechanism of cross-species immune recognition to falciparum malaria.

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Language(s): eng - English
 Dates: 2018-04-272018-07-242018-07-262019-01-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/infdis/jiy467
PMID: 30534974
 Degree: -

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Project name : -
Grant ID : RES0016099
Funding program : Open Operating Grant
Funding organization : Canadian Institutes of Health Research (CIHR)
Project name : -
Grant ID : -
Funding program : Canada Graduate Scholarship
Funding organization : Canadian Institutes of Health Research (CIHR)
Project name : -
Grant ID : RGPIN-2017–04179
Funding program : Discovery Grant
Funding organization : Natural Sciences and Engineering Research Council of Canada (NSERC)
Project name : -
Grant ID : -
Funding program : Postgraduate Scholarship-Doctoral
Funding organization : Natural Sciences and Engineering Research Council of Canada (NSERC)
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Grant ID : -
Funding program : Translational Research Grant
Funding organization : Li Ka Shing Institute of Virology
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Grant ID : -
Funding program : Stars in Global Health Award
Funding organization : Grand Challenges Canada
Project name : -
Grant ID : -
Funding program : Estrategia de Sostenibilidad
Funding organization : Universidad de Antioquia
Project name : -
Grant ID : -
Funding program : CREATE Host-Parasite Interactions Network
Funding organization : Natural Sciences and Engineering Research Council of Canada (NSERC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : COLCIENCIAS
Project name : -
Grant ID : -
Funding program : Research Exchange Scholarship
Funding organization : University of Alberta
Project name : -
Grant ID : -
Funding program : -
Funding organization : National Health and Medical Research Council (NHMRC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Alberta Innovates Health Solutions
Project name : -
Grant ID : -
Funding program : Intramural Research Program
Funding organization : National Institute of Allergy and Infectious Diseases

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Title: The Journal of Infectious Diseases
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Chicago, Ill. : Published by the University of Chicago Press for the Infectious Diseases Society of America
Pages: - Volume / Issue: 219 (1) Sequence Number: - Start / End Page: 110 - 120 Identifier: ISSN: 0022-1899
CoNE: https://pure.mpg.de/cone/journals/resource/954925414917_1