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  Gradients of connectivity distance in the cerebral cortex of the macaque monkey

Oligschläger, S., Xu, T., Baczkowski, B., Falkiewicz, M., Falchier, A., Linn, G., et al. (2019). Gradients of connectivity distance in the cerebral cortex of the macaque monkey. Brain Structure & Function, 224(2), 925-935. doi:10.1007/s00429-018-1811-1.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-BC70-C Version Permalink: http://hdl.handle.net/21.11116/0000-0004-4FD1-8
Genre: Journal Article

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 Creators:
Oligschläger, Sabine1, 2, 3, Author              
Xu, Ting 4, 5, Author
Baczkowski, Blazej1, 2, 3, 6, Author              
Falkiewicz, Marcel1, Author              
Falchier, Arnaud 5, Author
Linn, Gary 5, Author
Margulies, Daniel S.1, 3, 7, Author              
Affiliations:
1Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              
2Faculty of Life Sciences, University of Leipzig, Germany, ou_persistent22              
3International Max Planck Research School NeuroCom, Leipzig, Germany, ou_persistent22              
4Center for the Developing Brain, Child Mind Institute, New York, NY, USA, ou_persistent22              
5Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA, ou_persistent22              
6Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
7Centre National de la Recherche Scientifique, Paris, France, ou_persistent22              

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Free keywords: Cortical topography; Connectivity; Organizing principles; Primate phylogeny
 Abstract: Cortical connectivity conforms to a series of organizing principles that are common across species. Spatial proximity, similar cortical type, and similar connectional profile all constitute factors for determining the connectivity between cortical regions. We previously demonstrated another principle of connectivity that is closely related to the spatial layout of the cerebral cortex. Using functional connectivity from resting-state fMRI in the human cortex, we found that the further a region is located from primary cortex, the more distant are its functional connections with the other areas of the cortex. However, it remains unknown whether this relationship between cortical layout and connectivity extends to other primate species. Here, we investigated this relationship using both resting-state functional connectivity as well as gold-standard tract-tracing connectivity in the macaque monkey cortex. For both measures of connectivity, we found a gradient of connectivity distance extending between primary and frontoparietal regions. In the human cortex, the further a region is located from primary areas, the stronger its connections to distant portions of the cortex, with connectivity distance highest in frontal and parietal regions. The similarity between the human and macaque findings provides evidence for a phylogenetically conserved relationship between the spatial layout of cortical areas and connectivity.

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Language(s): eng - English
 Dates: 2017-12-262018-12-032018-12-132019-03
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00429-018-1811-1
PMID: 30547311
PMC: PMC6420469
Other: Epub 2018 Dec 13
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Funding organization : Max Planck Society

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Title: Brain Structure & Function
  Abbreviation : Brain Struct Funct
Source Genre: Journal
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Publ. Info: Berlin : Springer
Pages: - Volume / Issue: 224 (2) Sequence Number: - Start / End Page: 925 - 935 Identifier: ISSN: 1863-2653
CoNE: https://pure.mpg.de/cone/journals/resource/1863-2653