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  MP2RAGEME: T1, T2*, and QSM mapping in one sequence at 7 tesla

Caan, M. W. A., Bazin, P.-L., Marques, J. P., de Hollander, G., Dumoulin, S. O., & van der Zwaag, W. (2019). MP2RAGEME: T1, T2*, and QSM mapping in one sequence at 7 tesla. Human Brain Mapping, 40(6), 1786-1798. doi:10.1002/hbm.24490.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-BCD6-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-5F19-8
Genre: Journal Article

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 Creators:
Caan, Matthan W. A. 1, 2, Author
Bazin, Pierre-Louis1, 3, 4, Author              
Marques, José P. 5, Author
de Hollander, Gilles 6, Author
Dumoulin, Serge O. 1, 6, 7, Author
van der Zwaag, Wietske1, Author
Affiliations:
1Spinoza Centre for Neuroimaging, University of Amsterdam, the Netherlands, ou_persistent22              
2Department of Biomedical Engineering and Physics, VU University Medical Center, Amsterdam, the Netherlands, ou_persistent22              
3Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
4Social Brain Laboratory, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands, ou_persistent22              
5Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
6Department of Experimental and Applied Psychology, VU University Medical Center, Amsterdam, the Netherlands, ou_persistent22              
7Department of Experimental Psychology, Helmholtz Institute, Utrecht University, the Netherlands, ou_persistent22              

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Free keywords: QSM; Quantitative imaging; T1 mapping; T2* mapping
 Abstract: Quantitative magnetic resonance imaging generates images of meaningful physical or chemical variables measured in physical units that allow quantitative comparisons between tissue regions and among subjects scanned at the same or different sites. Here, we show that we can acquire quantitative T1, T2*, and quantitative susceptibility mapping (QSM) information in a single acquisition, using a multi‐echo (ME) extension of the second gradient‐echo image of the MP2RAGE sequence. This combination is called MP2RAGE ME, or MP2RAGEME. The simultaneous acquisition results in large time savings, perfectly coregistered data, and minimal image quality differences compared to separately acquired data. Following a correction for residual transmit B1+‐sensitivity, quantitative T1, T2*, and QSM values were in excellent agreement with those obtained from separately acquired, also B1+‐corrected, MP2RAGE data and ME gradient echo data. The quantitative values from reference regions of interests were also in very good correspondence with literature values. From the MP2RAGEME data, we further derived a multiparametric cortical parcellation, as well as a combined arterial and venous map. In sum, our MP2RAGEME sequence has the benefit in large time savings, perfectly coregistered data and minor image quality differences.

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Language(s): eng - English
 Dates: 2018-11-212018-07-042018-11-282018-12-132019-04-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/hbm.24490
PMID: 30549128
Other: Epub ahead of print
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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 40 (6) Sequence Number: - Start / End Page: 1786 - 1798 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686