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  Specific hippocampal choline decrease in an animal model of depression

Hong, S.-T., Choi, C.-B., Park, C., Park, C., Moon, H.-Y., Hong, K.-S., et al. (2009). Specific hippocampal choline decrease in an animal model of depression. British Journal of Radiology, 82(879), 549-553. doi:10.1259/bjr/25165760.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-BF96-E Version Permalink: http://hdl.handle.net/21.11116/0000-0002-BF97-D
Genre: Journal Article

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 Creators:
Hong, S-T1, 2, Author              
Choi, C-B, Author
Park, C, Author
Park, C, Author
Moon, H-Y, Author
Hong, K-S, Author
Cheong, C, Author
Chae, J-H, Author
Choe, B-Y, Author
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: A decreased level of the hippocampal choline signal was found in patients with depression in previous proton magnetic resonance spectroscopy (1H-MRS) studies. The objective of this study is to compare choline levels before and after the forced swimming test (FST), an animal model of depression typically used for assessing antidepressant activity. 1H-MRS spectra were obtained from both the left and right hippocampus. After the FST, rats showed a significant decrease of the choline/creatine (Cho/Cr, p = 0.037) and choline/N-acetylaspartate (Cho/NAA, p = 0.048) ratios in the left hippocampus, but not in the right hippocampus. This finding was analogous to results from patients with depression. It suggests that decreased Cho/Cr and Cho/NAA ratios in the left hippocampal regions might be considered to be biomarkers in rats with depression.

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 Dates: 2009-07
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1259/bjr/25165760
 Degree: -

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Title: British Journal of Radiology
  Other : Br. J. Radiol.
Source Genre: Journal
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Publ. Info: London : British Institute of Radiology
Pages: - Volume / Issue: 82 (879) Sequence Number: - Start / End Page: 549 - 553 Identifier: ISSN: 0007-1285
CoNE: https://pure.mpg.de/cone/journals/resource/954927708214