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  The Protective Action Encoding of Serotonin Transients in the Human Brain

Moran, R., Kishida, K., Lorenz, T., Saez, I., Laxton, A., Witcher, M., et al. (2018). The Protective Action Encoding of Serotonin Transients in the Human Brain. Neuropsychopharmacology, 43(6), 1425-1435. doi:10.1038/npp.2017.304.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-BFFF-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-C000-4
Genre: Journal Article

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https://www.nature.com/articles/npp2017304 (Publisher version)
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 Creators:
Moran, RJ, Author
Kishida, KT, Author
Lorenz, T, Author
Saez, I, Author
Laxton, AW, Author
Witcher, MR, Author
Tatter, SB, Author
Ellis, TL, Author
Phillips, PE, Author
Dayan, P1, Author              
Montague, PR, Author
Affiliations:
1External Organizations, ou_persistent22              

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 Abstract: The role of serotonin in human brain function remains elusive due, at least in part, to our inability to measure rapidly the local concentration of this neurotransmitter. We used fast-scan cyclic voltammetry to infer serotonergic signaling from the striatum of 14 brains of human patients with Parkinson’s disease. Here we report these novel measurements and show that they correlate with outcomes and decisions in a sequential investment game. We find that serotonergic concentrations transiently increase as a whole following negative reward prediction errors, while reversing when counterfactual losses predominate. This provides initial evidence that the serotonergic system acts as an opponent to dopamine signaling, as anticipated by theoretical models. Serotonin transients on one trial were also associated with actions on the next trial in a manner that correlated with decreased exposure to poor outcomes. Thus, the fluctuations observed for serotonin appear to correlate with the inhibition of over-reactions and promote persistence of ongoing strategies in the face of short-term environmental changes. Together these findings elucidate a role for serotonin in the striatum, suggesting it encodes a protective action strategy that mitigates risk and modulates choice selection particularly following negative environmental events.

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 Dates: 2018-05
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/npp.2017.304
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Title: Neuropsychopharmacology
Source Genre: Journal
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Publ. Info: New York, NY : No longer published by Elsevier
Pages: - Volume / Issue: 43 (6) Sequence Number: - Start / End Page: 1425 - 1435 Identifier: ISSN: 0893-133X
CoNE: https://pure.mpg.de/cone/journals/resource/954925558485