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  Block copolymer brush layer-templated gold nanoparticles on nanofibers for surface-enhanced Raman scattering optophysiology

Zhu, H., Lussier, F., Ducrot, C., Bourque, M.-J., Spatz, J. P., Cui, W., et al. (2019). Block copolymer brush layer-templated gold nanoparticles on nanofibers for surface-enhanced Raman scattering optophysiology. ACS Applied Materials and Interfaces, 11(4), 4373-4384. doi:10.1021/acsami.8b19161.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-C1E2-4 Version Permalink: https://hdl.handle.net/21.11116/0000-0005-FE6E-3
Genre: Journal Article

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ACSApplMaterInterfaces_11_2019_4373_Suppl.pdf (Supplementary material), 713KB
 
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 Creators:
Zhu , Hu, Author
Lussier, Félix, Author
Ducrot, Charles, Author
Bourque , Marie-Josee, Author
Spatz, Joachim P.1, 2, Author           
Cui, Wenli, Author
Yu, Li, Author
Peng, Wei, Author
Trudeau, Louis-Eric, Author
Bazuin, C. Geraldine, Author
Masson, Jean-François, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: SERS optophysiology; block copolymer brush; nanofiber; neurosciences; neurotransmitters
 Abstract: A nanothin block copolymer (BCP) brush-layer film adsorbed on glass nanofibers is shown to address the long-standing challenge of forming a template for the deposition of dense and well dispersed nanoparticles on highly curved surfaces, allowing the development of an improved nanosensor for neurotransmitters. We employed a polystyrene-block-poly(4-vinylpyridine) BCP and plasmonic gold nanoparticles (AuNPs) of 52 nm in diameter for the fabrication of the nanosensor on pulled fibers with diameters down to 200 nm. The method is simple, using only solution processes and a plasma cleaning step. The templating of the AuNPs on the nanofiber surprisingly gave rise to more than one order of magnitude improvement in the surface-enhanced Raman scattering (SERS) performance for 4-mercaptobenzoic acid compared to the same AuNPs aggregated on identical fibers without the use of a template. We hypothesize that a wavelength-scale lens formed by the nanofiber contributes to enhancing the SERS performance, to the extent that it can melt the glass nanofiber under moderate laser power. We then show the capability of this nanosensor to detect the co-release of the neurotransmitters dopamine and glutamate from living mouse brain dopaminergic neurons with a sensitivity one order of magnitude greater than with aggregated AuNPs. The simplicity of fabrication and the far superior performance of the BCP-templated nanofiber demonstrates the potential of this method to efficiently pattern nanoparticles on highly curved surfaces and its application as molecular nanosensors for cell physiology.

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Language(s): eng - English
 Dates: 2019-11-022019-01-072019-01-072019-01-30
 Publication Status: Issued
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1021/acsami.8b19161
URI: https://www.ncbi.nlm.nih.gov/pubmed/30615826
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Title: ACS Applied Materials and Interfaces
  Abbreviation : ACS Appl. Mater. Interfaces
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 11 (4) Sequence Number: - Start / End Page: 4373 - 4384 Identifier: ISSN: 1944-8244
CoNE: https://pure.mpg.de/cone/journals/resource/1944-8244