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  Pharmacological fingerprints of contextual uncertainty

Marshall, L., Mathys, C., Ruge, D., de Berker, A., Dayan, P., Stephan, K., et al. (2016). Pharmacological fingerprints of contextual uncertainty. PLoS Biology, 14(11), 1-31. doi:10.1371/journal.pbio.1002575.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-C2BD-E Version Permalink: http://hdl.handle.net/21.11116/0000-0002-C2BE-D
Genre: Journal Article

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Marshall, L, Author
Mathys, C, Author
Ruge, D, Author
de Berker, AO, Author
Dayan, P1, Author              
Stephan, KE, Author
Bestmann, S, Author
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1External Organizations, ou_persistent22              

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 Abstract: Successful interaction with the environment requires flexible updating of our beliefs about the world. By estimating the likelihood of future events, it is possible to prepare appropriate actions in advance and execute fast, accurate motor responses. According to theoretical proposals, agents track the variability arising from changing environments by computing various forms of uncertainty. Several neuromodulators have been linked to uncertainty signalling, but comprehensive empirical characterisation of their relative contributions to perceptual belief updating, and to the selection of motor responses, is lacking. Here we assess the roles of noradrenaline, acetylcholine, and dopamine within a single, unified computational framework of uncertainty. Using pharmacological interventions in a sample of 128 healthy human volunteers and a hierarchical Bayesian learning model, we characterise the influences of noradrenergic, cholinergic, and dopaminergic receptor antagonism on individual computations of uncertainty during a probabilistic serial reaction time task. We propose that noradrenaline influences learning of uncertain events arising from unexpected changes in the environment. In contrast, acetylcholine balances attribution of uncertainty to chance fluctuations within an environmental context, defined by a stable set of probabilistic associations, or to gross environmental violations following a contextual switch. Dopamine supports the use of uncertainty representations to engender fast, adaptive responses.

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Language(s): eng - English
 Dates: 2016-11
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1371/journal.pbio.1002575
eDoc: e1002575
 Degree: -

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Title: PLoS Biology
  Other : PLoS Biol.
Source Genre: Journal
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Publ. Info: San Francisco, California, US : Public Library of Science
Pages: - Volume / Issue: 14 (11) Sequence Number: - Start / End Page: 1 - 31 Identifier: ISSN: 1544-9173
CoNE: https://pure.mpg.de/cone/journals/resource/111056649444170