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  Parsing the role of the hippocampus in approach-avoidance conflict

Loh, E., Kurth-Nelson, Z., Berron, D., Dayan, P., Düzel, E., Dolan, R., et al. (2017). Parsing the role of the hippocampus in approach-avoidance conflict. Cerebral Cortex, 27(1), 201-215. doi:10.1093/cercor/bhw378.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-C2C4-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-C2C5-4
Genre: Journal Article

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Loh, E, Author
Kurth-Nelson, Z, Author
Berron, D, Author
Dayan, P1, Author              
Düzel, E, Author
Dolan, RJ, Author
Guitart-Masip, M, Author
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1External Organizations, ou_persistent22              

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 Abstract: The hippocampus plays a central role in the approach–avoidance conflict that is central to the genesis of anxiety. However, its exact functional contribution has yet to be identified. We designed a novel gambling task that generated approach–avoidance conflict while controlling for spatial processing. We fit subjects’ behavior using a model that quantified the subjective values of choice options, and recorded neural signals using functional magnetic resonance imaging (fMRI). Distinct functional signals were observed in anterior hippocampus, with inferior hippocampus selectively recruited when subjects rejected a gamble, to a degree that covaried with individual differences in anxiety. The superior anterior hippocampus, in contrast, uniquely demonstrated value signals that were potentiated in the context of approach–avoidance conflict. These results implicate the anterior hippocampus in behavioral avoidance and choice monitoring, in a manner relevant to understanding its role in anxiety. Our findings highlight interactions between subregions of the hippocampus as an important focus for future study.

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Language(s): eng - English
 Dates: 2017-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/cercor/bhw378
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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 27 (1) Sequence Number: - Start / End Page: 201 - 215 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440