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  Sensory Conflict Disrupts Activity of the Drosophila Circadian Network

Harper, R., Dayan, P., Albert, J., & Stanewsky, R. (2016). Sensory Conflict Disrupts Activity of the Drosophila Circadian Network. Cell Reports, 17(7), 1711-1718. doi:10.1016/j.celrep.2016.10.029.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-C315-A Version Permalink: http://hdl.handle.net/21.11116/0000-0002-C316-9
Genre: Journal Article

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 Creators:
Harper, REF, Author
Dayan, P1, Author              
Albert, JT, Author
Stanewsky, R, Author
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1External Organizations, ou_persistent22              

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 Abstract: Periodic changes in light and temperature synchronize the Drosophila circadian clock, but the question of how the fly brain integrates these two input pathways to set circadian time remains unanswered. We explore multisensory cue combination by testing the resilience of the circadian network to conflicting environmental inputs. We show that misaligned light and temperature cycles can lead to dramatic changes in the daily locomotor activities of wild-type flies during and after exposure to sensory conflict. This altered behavior is associated with a drastic reduction in the amplitude of PERIOD (PER) oscillations in brain clock neurons and desynchronization between light- and temperature-sensitive neuronal subgroups. The behavioral disruption depends heavily on the phase relationship between light and temperature signals. Our results represent a systematic quantification of multisensory integration in the Drosophila circadian system and lend further support to the view of the clock as a network of coupled oscillatory subunits.

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 Dates: 2016-11
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.celrep.2016.10.029
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Title: Cell Reports
Source Genre: Journal
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Publ. Info: Maryland Heights, MO : Cell Press
Pages: - Volume / Issue: 17 (7) Sequence Number: - Start / End Page: 1711 - 1718 Identifier: ISSN: 2211-1247
CoNE: https://pure.mpg.de/cone/journals/resource/2211-1247